Azetidin-2-one derivatives as serine protease inhibitors

Details Azetidin-2-one derivatives as serine protease inhibitors Azetidin-2-one derivatives as serine protease inhibitors

1991-05-07

1992-05-05

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540355, C07D20509, C07D20508, C07F 710, A61K 31395

Patent

active

051108127

ABSTRACT:
The present invention relates to new 3-guanidinoalkyl-2-azetidinones of the formula ##STR1## wherein: U and W can be the same or different and are selected from the group consisting of hydrogen and an amino protecting group;

REFERENCES:
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patent: 4637999 (1987-01-01), Doherty et al.
patent: 4680391 (1987-07-01), Firestone et al.
patent: 4699904 (1987-10-01), Doherty et al.
patent: 4717722 (1988-01-01), Doherty et al.
patent: 4845088 (1989-07-01), Doherty et al.
Doherty, et al., Cephalosporin Antibiotics Can Be Modified to Inhibit Human Leukocyte Elastase, Nature, 322, 10, p. 192 (1986).
Gianfranco, C., et al. Stereocontrolled Total Synthesis of Chiral Building Block (3S,4R)-3-[(R)-1-Hydroxyetheyl]-4-Acetyloxy-Azetidin-2-One: A Useful Synthon for the Synthesis of (+)-Thienamycin, Carbapenems and Penems. TETRAHEDRON LETTERS, 26, No. 7, pp.937-940, (1985).

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