Azepinones useful as intermediates in the preparation of inhibit

Details Azepinones useful as intermediates in the preparation of inhibit Azepinones useful as intermediates in the preparation of inhibit

1996-07-30

1999-01-05

Ford, John M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

540485, 540524, 540526, C07D22310

Patent

active

058564772

ABSTRACT:
The azepine intermediates of the formula ##STR1## wherein R.sub.6 and R.sub.7 are other than hydrogen are disclosed. These intermediates can be reacted with acylmercaptocarboxylic acids of the formula ##STR2## to give the pharmaceutically active products.

REFERENCES:
patent: 4105776 (1978-08-01), Ondetti et al.
patent: 4192945 (1980-03-01), Ondetti
patent: 4339600 (1982-07-01), Ondetti et al.
patent: 4374829 (1983-02-01), Harris et al.
patent: 4409146 (1993-10-01), Thorsett
patent: 4410520 (1983-10-01), Watthey
patent: 4415496 (1983-11-01), Harris et al.
patent: 4460579 (1984-07-01), Karanewsky
patent: 4465679 (1984-08-01), Huang et al.
patent: 4470988 (1984-09-01), Watthey
patent: 4473575 (1984-09-01), Watthey
patent: 4474778 (1984-10-01), Gordon et al.
patent: 4477464 (1984-10-01), Slade et al.
patent: 4512924 (1985-04-01), Attwood et al.
patent: 4533661 (1985-08-01), Karanewsky
patent: 4537885 (1985-08-01), Watthey
patent: 4539150 (1985-09-01), Katakami et al.
patent: 4548932 (1985-10-01), Sugihara et al.
patent: 4575503 (1986-03-01), Watthey
patent: 4584294 (1986-04-01), Ruyle
patent: 4587050 (1986-05-01), Harris et al.
patent: 4587238 (1986-05-01), Harris et al.
patent: 4594341 (1986-06-01), Cheung et al.
patent: 4617301 (1986-10-01), Patchett et al.
patent: 4629787 (1986-12-01), Harris et al.
patent: 4680392 (1987-07-01), Harris et al.
patent: 4699905 (1987-10-01), Yangisawa et al.
patent: 4711884 (1987-12-01), Karanewsky
patent: 4734410 (1988-03-01), Yanagisawa et al.
patent: 4749688 (1988-06-01), Haslanger
patent: 4824832 (1989-04-01), Flynn et al.
patent: 4873235 (1989-10-01), Parsons et al.
patent: 4963539 (1990-10-01), Delaney
patent: 4973585 (1990-11-01), Flynn et al.
patent: 5075302 (1991-12-01), Neustadt
patent: 5098934 (1992-03-01), Vevert et al.
patent: 5190974 (1993-03-01), Clemence et al.
patent: 5208236 (1993-05-01), Neustadt
patent: 5223516 (1993-06-01), Delaney
patent: 5225401 (1993-07-01), Seymour
patent: 5232920 (1993-08-01), Neustadt
patent: 5238924 (1993-08-01), Smith
patent: 5262436 (1993-11-01), Haslanger et al.
patent: 5362727 (1994-11-01), Robl
patent: 5366973 (1994-11-01), Flynn et al.
Greene, T.W. et al. Protective Groups in Organic Synthesis, (John Wiley & Sons, N.Y.), pp. 224-231 (1991).
Boyer, J.D. "Cirrhosis of the Liver and Its Major Sequelae" in Wyngaardon, J.B., et al., Girl Textbook of Medicine, vol. 1 (Philadelphia, Saunders Co., 1992), pp. 786-789.
Robl, J.A. et al. Bioorg. Med. Chem. Lett. 4, 1795-1800 (1994).
Robl et al., Biiorganic & Medicinal Chem. Letters, vol. 4, pp. 1795-1800, 1994, month of publication not provided.
Dussaule et al., Jour. of Clinical Endocrinology and Metabolism, vol. 72, pp. 653-659, 1991, month of publication not provided.
Loffi et al., Gastroenterology, vol. 96, pp. 167-177, 1989, month of publication not provided.
Fyhrquist et al., The Lancet, Dec. 21/28, 1985, p. 1439, month of publication not provided.
Fernandez-Cruz, The Lancet, Dec. 21/28, 1985, p. 1439-1440, month of publication not provided.
Naming and Indexing of Chemical Substances for Chemical Abstracts, 1987 Index Guide, Section 203, month of publication not provided.
Watthey et al., J. Med. Chem., 28, pp. 1511-1516 (1985), Publication month not provided.
Slade et al., J. Med. Chem., 28, pp. 1517-1521 (1985), Publication month not provided.
Thorsett et al., J. Med. Chem., 29, pp. 251-260 (1986), Publication month not published.
Yanagisawa et al., J. Med. Chem., 30, pp. 1984-1991 (1987), Publication month not provided.
Yanagisawa et al., J. Med. Chem., 31, pp. 422-428 (1988), Publication month not provided.
Parsons et al., Biochem and Biophysical Research Comm. 117, pp. 108-113 (1993), Publication month not provided.
Atwood et al., FEBS Letters, vol. 165, pp. 201-206 (1984), Publication month not published.
Natoff et al., Drugs Of the Future, vol. 12, pp. 475-483 (1987), Publication month not provided.
Itoh et al., Chem. Pharm. Bull., vol. 34, pp. 1128-1147 and 2078-2089 (1986), Publication month not provided.
Flynn, Tetrahedron Letters, vol. 31, pp. 815-818 (1990), Publication month not provided.
Thorsett, Actual Chim. Ther., vol. 13, pp. 257-268 (1986), Publication month not provided.
Atwood et al., J. Chem. Soc. Perkin Trans I (1986) pp. 1011-1019, Publication month not provided.
Robl, Tetrahedron Letters, vol. 35, pp. 393-396 and 1393-1396, (1994), Publication month not provided.
Delaney et al., Bioorganic & Medicinal Chemistry Letters, vol. 4, pp. 1783-1788 (1994), Publication month not provided.
Robl et al., Bioorganic & Medicinal Chemistry Letters, vol. 4, pp. 1789-1794 (1994), Publication month not provided.
Robl et al., Bioorganic & Medicinal Chemistry Letters, vol. 4, pp. 2055-2060 (1994), Publication month not provided.
Das et al., Bioorganic & Medicinal Chemistry Letters, vol. 4, pp. 2193-2198 (1994), Publication month not provided.
Bolos et al., J. Org. Chem., 57, 3535-3539 (1992), Publication month not provided.
Bolos et al., Tetrahedron, vol. 48, pp. 9567-9576 (1992), Publication month not provided.
Adams et al., Synthetic Communications, vol. 18, 2225-2231 (1988), Publication month not provided.
Chackalamannil et al., Bioorganic & Medicinal Chemistry Letters, vol. 2, pp. 1003-1006 (1992), Publication month not provided.
Flynn et al., J. Med. Chem., 36, pp. 2420-2423 (1993), Publication month not provided.
Robl et al., J. Am. Chem. Soc., 116, pp. 2348-2355 (1994), Publication month not provided.

Affiliated with

Also associated with

Rating

Azepinones useful as intermediates in the preparation of inhibit does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Azepinones useful as intermediates in the preparation of inhibit, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Azepinones useful as intermediates in the preparation of inhibit will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-863599