Azepinone compounds useful in the inhibition of ACE and NEP

Details Azepinone compounds useful in the inhibition of ACE and NEP Azepinone compounds useful in the inhibition of ACE and NEP

1999-07-21

2000-11-07

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

C07D22332

Patent

active

061438863

ABSTRACT:
Compounds having the following formulae I and II, and pharmaceutically acceptable salts thereof, including dual inhibitors of ACE and NEP and selective ACE inhibitors: ##STR1## and wherein R, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.5a, R.sup.5b, R.sup.6, R.sup.7, R.sup.11, q and r are defined herein.

REFERENCES:
Robl et al., Peptidomimetic Synthesis: A Novel, Highly Stereoselective Route to Substituted Freidinger Lactams, Journal of the American Chemical Society, vol. 16, No. 6, pp. 2348-2355, Mar. 1994.
Sreenivasan et al., Synthesis and Dopamine Receptor Modulating Activity of Lactam Conformationally Constrained Analogues of Pro-Leu-Gly-NH.sub.2, Journal of Medicinal Chemistry, vol. 36, No. 2, pp. 256-263, 1993.

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