Azepinone compounds useful in the inhibition of ACE and NEP

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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514 80, 514212, 514 79, 514 84, 514 89, 514 90, 514 91, 540523, 540487, 540524, 540527, C07D22332, A61K 3155

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055873758

ABSTRACT:
Compounds having the following formulae I and II, and pharmaceutically acceptable salts thereof, including dual inhibitors of ACE and NEP and selective ACE inhibitors: ##STR1## and wherein R, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.5a, R.sup.5b, R.sup.6, R.sup.7, R.sup.11, q and r are defined herein.

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