Azepino[4,5-d]indole derivatives and preparation thereof

Details Azepino[4,5-d]indole derivatives and preparation thereof Azepino[4,5-d]indole derivatives and preparation thereof

1982-09-29

1984-01-31

Daus, Donald G.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07D48704

Patent

active

044288808

ABSTRACT:
This invention relates to novel tetrahydroazepinoindoles used in the preparation of novel alkyl pyrrolo(2,3-d)carbazole-6-carboxylates and to addition salts thereof; and to preparation of the same by a synthesis sequence starting from a tryptamine and a 3-halopyruvate and involving a rearrangement of the reaction mixture, said rearrangement being effected by heating the reaction mixture in the presence of a base. The pyrrolo(2,3-d)carbazole final products have both antianoxic and psychotropic activities.

REFERENCES:
patent: 3478051 (1969-11-01), Houlihan et al.
patent: 4154943 (1979-05-01), Kuehne
patent: 4220774 (1980-09-01), Kuehne
patent: 4267330 (1981-05-01), Kuehne
patent: 4272539 (1981-06-01), Koletar et al.
patent: 4277476 (1981-07-01), DuPont et al.

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