Azepine or larger medium ring derivatives and methods of use

Details Azepine or larger medium ring derivatives and methods of use Azepine or larger medium ring derivatives and methods of use

1998-12-16

2000-08-22

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514211, 540484, 540596, 540604, A61K 3140, C07D48704, C07D22302

Patent

active

061072915

ABSTRACT:
Selected novel azepine and larger medium ring compounds are effective for prophylaxis and treatment of inflammation, tissue degradation and related diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of inflamation, tissue degradation and related diseases. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

REFERENCES:
patent: 5552419 (1996-09-01), MacPherson
Reich et al., J. Amer. Chem. Soc., 97:19, p. 5434 (1975).
Svensson et al., Drug Metabolism Reviews, 19(2), 165-194 (1988).
Bundgaard, J. Med. Chem., 32(12), 2503 (1989).
Baldwin et al., Tetrahedron, 45(19), 6309 (1989).
Schuster et al., Angew. Chem. Int. Ed. Engel, 36:2036-2056 (1997).
Ninomiya et al., Tetrahedron, 30:2151 (1974).
Wadsworth, Organic Reactions, 25:73-253 (1977).
Rabjohn, Organic Reactions, 24:261-415 (1976).
Posner, Organic Reactions, 19:1-113 (1972).
Gearing et al., Nature, 370:555-557 (1994).
Mohler et al., Nature, 370:218-220 (1994).
Shohami et al., J. Cereb. Blood Flow Metab., 14:615-619 (1994).
Lahdevirta et al., The American J. Med., 85:289 (1988).
Clouse et al., J. Immunol., 142:431-438 (1989).
Maini et al., Immunological Reviews, No. 144, pp. 195-223 (1995).
McGeehan et al., Nature, 370:558-561 (1994).
Liu et al., Neuroscience Letters, 164:125-128 (1993).
Liu et al., Stroke, 25:1481-1488 (1994).

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