Azepans and methods for making and using same

Details Azepans and methods for making and using same Azepans and methods for making and using same

2011-06-28

2011-06-28

Jarrell, Noble (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

Reexamination Certificate

active

07968708

ABSTRACT:
Disclosed are compounds having the formula:wherein Z1is an alkylene moiety; Q is a carboxylic acid derivative; and R1and R2are the same or different and are selected from the group consisting of alkyl, aryl, alkylcarbonyl, arylcarbonyl, hydroxycarbonyl, and alkoxycarbonyl or R1and R2, taken together with the nitrogen atom to which they are bound, form a ring. Also disclosed are compounds having the formula:wherein Z1is an alkylene moiety; Q is a carboxylic acid derivative; and R13is selected from the group consisting of alkyl and aryl. The compounds can be used to modulate cell proliferation and/or apoptosis, for example, in the treatment of cancers and other proliferative diseases, disorders, and conditions.

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