Azepanes and their ring homologues having protein kinase inhibit

Details Azepanes and their ring homologues having protein kinase inhibit Azepanes and their ring homologues having protein kinase inhibit

1996-09-03

1998-05-12

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548556, 548200, 548201, 548215, 5483147, 548236, 5462784, 5462787, 544372, 544 52, C07D20712, C07D40112

Patent

active

057507066

ABSTRACT:
The compounds of formula I ##STR1## wherein R.sup.1 -R.sup.9, R.sup.15, A, X, Y, Z and n have the meaning given in the specification are active as protein kinase inhibitors and can be used as medicaments, particularly for the treatment of inflammatory skin disorders and alopecia.

REFERENCES:
Kulanthaivel et al., J. Am. Chem. Soc., 115:6452-6453 (1993).
Muller et al., Leibigs Annalen Der Chemie, Nr. 6, 651-655 (1993).
Koenig et al., Chem. Berichte, 112:2221-2226 (1980).

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