Azavesamicols

Details Azavesamicols Azavesamicols

1992-06-03

1994-08-16

Cintins, Marianne M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D21140

Patent

active

053388526

ABSTRACT:
The compounds are vesamicol (hydroxylated phencyclidine (PCP) isomer trans-2-(4-phenyl-piperidino)cyclohexanol) derivatives with anticholinergic properties termed herein "azavesamicols" in which the cyclohexyl group of vesamicol is replaced with a heterocycle of similar size, the piperidyl ring. The compounds bind to the vesamicol receptor, a cytoplasmically-oriented site on the cholinergic synaptic vesicle, which is associated with the vesicular transporter of acetylcholine.

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Widen, Eriksson, Ingvar, Parsons, Rogers and Stone-Eander, Neurosci. Lett. 136, 1-4, 1990.

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