Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – In an organic compound
Patent
1997-08-04
1999-03-02
Rotman, Alan L.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
In an organic compound
424 93, 546188, A81K 5104, C07D21140
Patent
active
058766944
ABSTRACT:
A method for non-invasively mapping cholinergic innervation in a living brain comprises injecting the brain with a radiolabelled vesamicol (hydroxylated phencyclidine (PCP) isomer trans-2-(4-phenyl-piperidino)cyclohexanol) derivatives with anticholinergic properties termed herein "azavesamicols" in which the cyclohexyl group of vesamicol is replaced with heterocycle of similar size, the piperidyl ring. The radiolabel is then detected externally with a photoscanning device.
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Efange Simon Mbua Ngale
Parsons Stanley M.
Aulakh Charanjit S.
Brennan Leoniede M.
Regents of the University of California
Regents of the University of Minnesota
Rotman Alan L.
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