Azasteroid compounds for the treatment of prostatic hypertrophy,

Details Azasteroid compounds for the treatment of prostatic hypertrophy, Azasteroid compounds for the treatment of prostatic hypertrophy,

1993-02-26

1994-04-12

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514253, 514256, 544238, 544295, 544296, 544333, 544335, 544336, 544405, 546 77, A61K 3158, C07J 7300

Patent

active

053026217

ABSTRACT:
Compounds of formula (I): ##STR1## (in which: R.sup.1 is a hydrogen atom, an unsubstituted alkyl group, an aryl-substituted alkyl group or a heterocyclic-substituted alkyl group; R.sup.2 is an aryl-substituted alkyl group, a heterocyclic-substituted alkyl group or a diarylamino group; R.sup.3 is a hydrogen atom, an unsubstituted alkyl group, an aryl-substituted alkyl group or an alkenyl group having from 3 to 6 carbon atoms; and each of the bonds represented by .alpha.-.beta. and .gamma.-.delta. is a carbon-carbon single bond or a carbon-carbon double bond;) and pharmaceutically acceptable salts and esters thereof are useful for the treatment and prophylaxis of prostatic hypertrophy. We also provide processes for their preparation.

REFERENCES:
patent: 4179453 (1979-12-01), Johnston
patent: 4220775 (1980-09-01), Rasmusson
patent: 4377584 (1983-03-01), Rasmusson
patent: 4732897 (1988-03-01), Cainelli et al.
patent: 4760071 (1988-07-01), Rasmusson
patent: 5021575 (1991-06-01), King
Padilla, The Prostate 6, 129-143 (1985).
Petrow The Prostate, 6, 169-182 (1985).
Rasmusson et al, "Azasteroids: Structure-Activity Relationships for Inhibition of 5.alpha.-Reductase and of Androgen Receptor Binding", 1986, vol. 29, pp. 2298-2315, Journal of Medicinal Chemistry.

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