Azaprostanoic acid analogs and their use as inhibitors of platel

Details Azaprostanoic acid analogs and their use as inhibitors of platel Azaprostanoic acid analogs and their use as inhibitors of platel

1978-09-12

1980-12-16

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

560121, 562503, 424319, C07C10104, A61K 31557

Patent

active

042397782

ABSTRACT:
Novel azaprostanoic acid analogs of the formula ##STR1## wherein: R is C.sub.1 to C.sub.8 alkyl or benzyl; and a has a value of from 0 to 6 inclusive, and their pharmaceutically acceptable salts and esters. Preferred 13-aza and 15-aza compounds are active in the inhibition of arachidonic acid-induced platelet aggregation and, more specifically, are direct and specific antagonists of the activity of prostaglandin H.sub.2 and thromboxane A.sub.2.

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