Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1986-07-15
1987-05-26
Friedman, Stanley J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
A61K 3153
Patent
active
046686762
ABSTRACT:
Azapropazone can be used to prevent post-ischemic tissue damage in mammals.
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McCord, J. M.: "Oxygen-Derived Free Radicals in Post-Ischemic Tissue Injury," New England Journal of Medicine, 312:154-163, 1985.
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Rossen, R. D., et al.: "Selective Accumulation of First Component of Complement and Leukocytes in Ischemic Canine Heart Muscle," Cir. Res. 57:119-129, 1985.
Bednar, M., et al.: "Nafazatrom-Induced Salvage of Ischemic Myocardium in Anesthetized Dogs is Mediated Through Inhibition of Neutrophil Function," Circ. Res. 57:131-141, 1985.
Templeton, J. S.: "Azapropazone, in Anti-Rheumatic Drugs," vol. 3 (Edited by E. C. Huskisson), Praeger Publishers, New York, p. 97 (1983).
Bulkley, G. B.: "Role of Oxygen-Derived Free Radicals in Human Diseases: Immediate and Long Range Applications for Antioxidant Therapy in Clinical Medicine," Program & Abstracts, 19th National Medicinal Chemistry Symposium, Tuscon, Arizona, Jun. 17-21, 1984.
Jones, H. P., et al., "Effect of Allopurinol of Neutrophil Superoxide Production, Chemotaxis or Degranulation," Biochemical Pharmacology, vol. 34, No. 20, pp. 3673-3676, 1976.
Boswell George A.
Mackin William M.
Thoolen Martin J.
E.I. Du Pont de Nemours and Company
Friedman Stanley J.
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