Azapeptide acids as cell adhesion inhibitors

Details Azapeptide acids as cell adhesion inhibitors Azapeptide acids as cell adhesion inhibitors

1998-10-16

2000-05-30

Ramsuer, Robert W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

314247, 544224, 5483561, A61K 31415, A61P 3708, C07D23104

Patent

active

060691638

ABSTRACT:
Azapeptide acids of Formula I are antagonists of VLA-4 and/or .alpha..sub.4 .beta..sub.7, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds may be formulated into pharmaceutical compositions and are suitable for use in the treatment of asthma, allergies, inflammation, multiple sclerosis, and other inflammatory and autoimmune disorders.

REFERENCES:
patent: 4431659 (1984-02-01), Sakai et al.
Bioorganic & Medicinal Chem Letters vol. 6 No. 21 pp. 2495-2500, 1996.
Med. Chem. 1997, 40, 3359-3368.
Bioorganic Med. Chem. Letter vol. 8, 2297 (1998).

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