Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-06-22
1995-08-29
Cintins, Marianne M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
A61K 31445
Patent
active
054460492
ABSTRACT:
This invention relates to methods of treating conditions responsive to 5-HT.sub.4 agonists and/or antagonists and 5-HT.sub.3 antagonists by administering compounds of the formula: ##STR1## or a pharmaceutically acceptable salt thereof wherein Z is selected from the group consisting of ##STR2## R.sub.1 is alkoxy of one to six carbon atoms; R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are the same or different and are selected from the group consisting of hydrogen, halogen, CF.sub.3, hydroxy, alkoxy of one to six carbon atoms, acyl of two to seven carbon atoms, amino, amino substituted by one or two alkyl groups of one to six carbon atoms, C.sub.2 -C.sub.7 acylamino, aminocarbonyl, aminosulfone optionally substituted by one or two alkyl groups of one to six carbon atoms, C.sub.1 -C.sub.6 alkylsulfone and nitro;
REFERENCES:
patent: 4578382 (1986-03-01), Jarreau et al.
patent: 4816453 (1989-03-01), Watts
patent: 4950759 (1990-08-01), Wijngaarden et al.
patent: 4992461 (1991-02-01), Zabrowski et al.
patent: 5001133 (1991-03-01), Richardson et al.
patent: 5126343 (1992-06-01), Zabrowski et al.
patent: 5137893 (1992-08-01), Becker et al.
patent: 5140023 (1992-08-01), Becker et al.
Sandoz, A. G., New N-oxide(s) of alkylene bridged piperidinol etc. Derwent Abstract, 89/179167/25 1989.
R. C. Bick et al., Aristofruticosine, A Novel Indole Alkaloid etc. Tetrahedron Letters, vol. 29 No. 27 3355-3356 1988.
Theo R. Bok et al., 3-Azanoradamantanes Heterocycles, vol. 12, No. 3 343-347 1979.
Rene Beerlie et al., Synthesis of Aristotelia-Type Alkaloids Helvetica Chimica Acta vol. 74 110-116 1991.
Flynn Daniel L.
Moormann Alan E.
Cintins Marianne M.
G. D. Searle & Co.
Kovacevic Cynthia S.
Spivack Phyllis G.
Williams Roger A.
LandOfFree
Azanoradamantanes for treatment of conditions responsive to 5-HT does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Azanoradamantanes for treatment of conditions responsive to 5-HT, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Azanoradamantanes for treatment of conditions responsive to 5-HT will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1819613