Azaindolylidene derivatives as kinase inhibitors, process...

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C548S322500

Reexamination Certificate

active

07371862

ABSTRACT:
The present invention is directed to compounds of the formulaor pharmaceutically acceptable salts, prodrug, solvate or optical isomer thereof, pharmaceutical compositions containing same and use thereof for treating diseases linked to disregulated cell proliferation or to disregulated protein kinase.

REFERENCES:
patent: 2002/0022624 (2002-02-01), Dinnell et al.
patent: 2 298 198 (1996-08-01), None
patent: 2 298 199 (1996-08-01), None
patent: WO 94/14808 (1994-07-01), None
patent: WO 96/00226 (1996-01-01), None
patent: WO 97/49703 (1997-12-01), None
patent: WO 01/09121 (2001-02-01), None
patent: WO 01/98299 (2001-12-01), None
patent: WO 02/16348 (2002-02-01), None
patent: WO 03/000688 (2003-01-01), None
patent: WO 2006/040049 (2006-04-01), None
Cohen P., “The Development and Therapeutic Potential of Protein Kinase Inhibitors”,Current Opinion in Chemical Biology, 3:459-465 (1999).
Hosoi T. et al., “Evidence for cdk5 as a Major Activity Phosphorylating Tau Protein in Porcine Brain Extract”,J. Biochem., 117(4):741-749 (1995).
Patani G.A. et al., “Bioisosterism: A Rational Approach in Drug Design”,Chem. Rev., 96:3147-3176 (1996).
Fleisher D. et al., “Improved Oral Drug Delivery: Solubility Limitations Overcome by the Use of Prodrugs”,Advanced Drug Delivery Reviews, 19:115-130 (1996).
Robinson R.P. et al., “Discovery of the Hemifumarate and (α-L-Alanyloxy)Methyl Ether as Prodrugs of an Antirheumatic Oxindole: Prodrugs for the Enolic OH Group”,J. Med. Chem., 39:10-18 (1996).
Verbiscar A.J., “Sythesis of 1-p-Chlorobenzyl-7-Azaindole-3-α-Piperidylmethanol as a Potential Antimalarial Agent”,Journal of Medicinal Chemistry, 15(2):149-152 (1972).
Gálvez C. et al., “Reactivity of 1H-Pyrrolo[2,3-b]Pyridine. I. Synthesis of 3-Acetyl-7-Azaindole and Related Compounds”,J. Heterocyclic Chem., 19:665-667 (1982).
Williams D.L. et al., “The Glyoxalines. V. The Bromination of 2-Phenyl-4-Benzal-5-Glyoxalidone”,J. Am. Chem. Soc., 68:647-649 (1946).
Khodair A.I. et al., “Synthesis, Conformational Analysis and Antitumor Testing of 5-(Z)-Arylidene-4-Imidazolidinone Derivatives”,Phosphorus, Sulfur and Silicon, 140:159-181 (1998).

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