Azaindoles as inhibitors of c-Jun N-terminal kinases

Details Azaindoles as inhibitors of c-Jun N-terminal kinases Azaindoles as inhibitors of c-Jun N-terminal kinases

2007-11-06

2007-11-06

Dentz, Bernard (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C546S113000

Reexamination Certificate

active

10509127

ABSTRACT:
The present invention relates to novel 5-substituted 7-azaindole compounds of formula (I), their use in the inhibition of c-Jun N-terminal kinases, their use in medicine and particularly in the prevention and/or treatment of neurodegenerative disorders related to apoptosis and/or inflammation. The invention also provides processes for manufacture of said compounds, compositions containing them and processes for manufacturing such compositions

REFERENCES:
patent: 6642375 (2003-11-01), Inomata et al.
patent: 0737685 (1996-10-01), None
patent: 1106621 (2001-06-01), None
patent: WO-9921859 (1999-05-01), None
patent: WO-0035909 (2000-06-01), None
patent: WO-0035921 (2000-06-01), None
patent: WO-0056710 (2000-09-01), None
patent: WO-0112609 (2001-02-01), None
patent: WO-0147922 (2001-07-01), None
patent: WO-0149288 (2001-07-01), None
patent: WO01049288 (2001-07-01), None
patent: WO-0216359 (2002-02-01), None
patent: WO-02081475 (2002-10-01), None
patent: WO-03082869 (2003-10-01), None
CAS Accession No. 2001:432896, Registry No. 344454-31-1.
CAS Document No. 135:43132.
West, Anthony R., Solid State Chemistry and its Applications (Wiley, New York, 1988).
Bundgaard, Design of Prodrugs (Elsevier Science Publishers 1985).
Smulik and Diver, Synthesis of Cyclosporin A-Derived Affinity Reagents by Olefin Metathesis, Organic Letters, 4(12):2051-2054 (2002).
LeConte, Reach-Through Claims, International Pharmaceutical (2002) (also available at <http://www.bakerbotts.com/infocenter/publications/detail.aspx?id=bffe4a7d-5beb-dcf8-a189-15a5f190f0eb>).
Silva, Reach Through Claims: Bust or Boon?, Intellectual Property Update (available at: <http://www.dorsey.com/publications/legal—detail.aspx?FlashNavID=pubs—legal&pubid=170565003>).
Vippagunta et al., Crystalline Solids, Advanced Drug Delivery Reviews, 48(1): 3-26 (2001).
CAS Document No. 135:107148.
Cao, J. et al., “Distinct Requirements for p38α and c-Jun N-terminal Kinase Stress-activated Protein Kinases in Difference Forms of Apoptotic Neuronal Death.”The Journal of Biological Chemistry. 2004. vol. 279, No. 34, 359033-13.
Eilers, A. et al., “Direct inhibition of c-Jun N-terminal kinase in sympathetic neurons prevents c-jun-promoter activation and NGF withdrawal-induced death”Journal of Neurochemistry, 1998. 76, 1439-54.
Eilers, A. et al., “Role of the Jun Kinase Pathway in the Regulation of c-Jun Expression and Apoptosis in Sympathetic Neurons”The Journal of Neuroscience. 1998 . 8(5), 1713-24.
Estus, S. et al., “Aggregated Amyloid-β Protein Induces Cortical Neuronal Apoptosis and Concomitant “Apoptotic” Pattern of Gene Induction.”The Journal of Neuroscience.1997. 17(20), 7736-45.
Ham, J. et al., “A c-Jun Dominant Negative Mutant Protects Sympathetic Neurons against Programmed Cell Death”Neuron. 1995. vol. 14, 927-39.
Lisnock, J. et al., “Activation of JNK3∝1 Requires both MKK4 and MKK7: Kinetic Characterization of in Vitro Phosphorylated JNK3∝1”Biochemistry. 2000. vol. 39, 3141-48.
Watson, A. et al., “Phosphorylation of c-Jun Is Necessary for Apoptosis Induced by Survival Signal Withdrawal in Cerebellar Granule Neurons”The Journal of Neuroscience. 1998. 18(2), 751-62.
Young, P. R. et al., “Pyridinyl Imidazole Inhibitors of p38 Mitogen-activated Protein Kinase Bind in the ATP Site”The Journal of Biological Chemistry, 1997. vol. 272, No. 18, 12116-21.

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