Azaindoles

Details Azaindoles Azaindoles

2005-05-24

2005-05-24

Raymond, Richard L. (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S299000, C514S300000, C514S410000, C546S113000, C546S126000

Reexamination Certificate

active

06897207

ABSTRACT:
The invention is directed to physiologically active compounds of general formula (I):and compositions containing such compounds; and their prodrugs, and pharmaceutically acceptable salts and solvates of such compounds and their prodrugs, as well as to novel compounds within the scope of formula (I). Such compounds and compositions have valuable pharmaceutical properties, in particular the ability to inhibit kinases.

REFERENCES:
patent: 5338849 (1994-08-01), Didier
patent: 5521213 (1996-05-01), Prasit
patent: 5681959 (1997-10-01), Bishop
patent: 5714495 (1998-02-01), Viaud
patent: 6025366 (2000-02-01), Walsh
patent: 6169091 (2001-01-01), Cockerill
patent: 6207699 (2001-03-01), Cockerill
patent: 6232320 (2001-05-01), Stewart
patent: 6348487 (2002-02-01), Connor
patent: 6384235 (2002-05-01), Henkelmann
patent: 6387900 (2002-05-01), Pevarello
patent: 6407259 (2002-06-01), Harris
patent: 0405602 (1991-01-01), None
patent: 509974 (1992-10-01), None
patent: 0509974 (1992-10-01), None
patent: 0557171 (1995-07-01), None
patent: 0716855 (1996-06-01), None
patent: 0737685 (1996-10-01), None
patent: 1086950 (2001-03-01), None
patent: 966.264 (1964-08-01), None
patent: 2298199 (1996-08-01), None
patent: 06-247966 (1994-09-01), None
patent: WO9510513 (1995-04-01), None
patent: WO9606840 (1996-03-01), None
patent: WO9806703 (1998-02-01), None
patent: WO9822457 (1998-05-01), None
patent: 9822457 (1998-05-01), None
patent: WO9847899 (1998-10-01), None
patent: WO9920624 (1999-04-01), None
patent: WO0130774 (1999-10-01), None
patent: WO9951231 (1999-10-01), None
patent: WO9951232 (1999-10-01), None
patent: WO9951234 (1999-10-01), None
patent: WO9951595 (1999-10-01), None
patent: WO9958518 (1999-11-01), None
patent: WO0017202 (2000-03-01), None
patent: WO0040547 (2000-07-01), None
patent: WO0075117 (2000-12-01), None
patent: WO0102369 (2001-01-01), None
patent: WO0130774 (2001-05-01), None
patent: WO0147922 (2001-07-01), None
patent: WO0153268 (2001-07-01), None
patent: WO0160816 (2001-08-01), None
patent: WO0162252 (2001-08-01), None
patent: WO0130774 (2001-10-01), None
patent: WO0172720 (2001-10-01), None
patent: WO0196336 (2001-12-01), None
patent: WO0210137 (2002-02-01), None
patent: WO0130774 (2002-03-01), None
patent: WO0222601 (2002-03-01), None
patent: WO0222602 (2002-03-01), None
patent: WO0222603 (2002-03-01), None
patent: WO0222604 (2002-03-01), None
patent: WO0222605 (2002-03-01), None
patent: WO0222606 (2002-03-01), None
patent: WO0222607 (2002-03-01), None
patent: WO03000688 (2003-01-01), None
Chemical Abstract DN 71:49810, also cited as J. Chem Soc. 11, 1505-14(1969).*
Chemical Abstract DN 116:174021, also cited as Tetrahedron, 48/5,939062(1992).*
Chemical Abstract DN 129:352830, also cited as WO 9822457 dated May 1998.*
Chemical Abstract DN 125:167834, also cited as Synthesis, 7,877-82(1996).*
Chemical Abstract DN118:101981, also cited as EP509974.*
Chemical Abstract DN 116:174021, also cited as Tetrahydron,48/5,939-52(1992).*
Chemical Abstract DN 125:167834, also cited as Synthesis, 7,877-882(1996).*
Chemical Abstract DN 133:252337, also cited as Angewandte Chemie, International Edition, 39/14,2488-2490(2000).*
Chemical ASbstract DN 132:317221, also cited as J. Am. Chem. Soc., 122/15,3671-3678(2000).*
Chemical Abstract DN 132:303464, also cited as J. Receptor & Signal Transduction Research, 20/1,105-118(2000).*
Cecil TextBook of Medicine, 20thedition, vol. 2, pp. 19921996(1996).*
PubMed Abstract 12467573, also cited as Structure(Camb), 1 '0/12,1659-67(2002).*
PubMed Abstract 14522925, also cited as Cancer res., 63/18,5978-91(2003).*
U.S. Appl. No. 09/847,962, filed May 2, 2001, Li.
Busev et al.. Extraction-Photometric Determination of Molybdenum by Means of 6.7-Dihydroxy-2,4-Diphenylbenzopyrillum Chloride, Zhum. Analit. Khimii, vol. 16, pp. 571-577, 1961.
Chumakov, Yu I. et al., 3-Formyl-7-Azaindoles, Byulleten Izobretnii Tovamykh Znakor, V. 10, p. 22, 1964, Su 162534.
Clark, B. A. J. et al., Mass Spectrometry of Pyrrolo[2,3-b]pyrazines and Pyraziono[2,3-b]indole, Org. Mass Spectrom, vol. 12(7), pp. 421-423, 1977.
Clark, Bernard A. J. et al., Preparation of pyrrolo[2,3-b]pyrazines and pyrazino[2,3-b]indole. Chemistry and Industry (London), 1975, pp. 215-216.
Clark, B. A. J. et al., Formation of Certain Substituted 5H-Pyrrolo[2,3-b]pyrazines by Thermal Cyclisaton of Pyrazinlhydrazones and a Route to 5H-Pyrazino[2,3-b]indole: a Synthesis of 5H-Pyrrolo[2,3-b] pyrazine and Some of its Properties, Journal of Chemical Society, Perkin Transactions 1, vol. 1(13), pp. 1361-1363, 1976.
Davis, Michael L. et al., Reactions of beta-Lihiomethyl)azines with Nitriles as a Route to Pyrrolo-pyridines, -quinolines, -pyrazines, -quinoxalines and -pyrimidines, Tetrahedron, vol. 48, No. 5, pp. 939-952, 1992.
Hands, David et al., A Convenient Method of the Preparation for 5-, 6-and 7-Azaindoles and Their Derivatives, Synthesis, Jul. 1996, (Jul. 1996), pp. 877-882.
Hardy, O. R. et al., Ring Opening or Rearrangement vs. N-Oxidation in the Action of Peracids upon Pyrrolo[2,3b]pyridines, Pyrrolo[2,3b]pyrazines, & Triazolo[1,5-a]-& Triazolo[4,3-a]-pyrazine. Some Chemical and Spectroscopic Properties of the Triazolopyrazines & Their N-Oxides, J.C.S., Perkin Trans.1. 506-511, 1980.
Henry, James R. et al., 6-amino-2(4-flurophnyl)-4-methoxy-3-(4-pyridyl)-1H-pyrrolo[2,3b]pyrdine (RWY 68354): A Potent and Selective p38 Kinase Inhibitor, J. Med. Chem., vol. 41, No. 22, 4196-4198, 1998.
Herbert, R. et al., 1H-Pyrrolo[2,3-b]pyridines. Part II. Fragmentation of Some 1H-Pyrrolo[2,3-b]pyridines induced by Electron Impact, Journal of the Chemical Society Sect. B. Physical Organic, 1970, vol. 3, pp. 459-463.
Herbert, R. et al., Syntheses and Properties of 1H-Pyrrolo[2,3-b]pyridines, J. Chem. Soc., 1969, pp. 1505-1514.
Kruse, C. G. et al., Furo- and Thieno[2,3-b]pyrazines, Part 2. Chemical Properties of 2-Substituted Derivatives, Recueil des Travaux Chimiques des Pays-Bas, Journal of the Royal Netherlands Chemical Society, vol. 97(6), pp. 151-155, 1978.
Marot, Christophe et al., Pharmacophoric Search and 3D-QSAR Comparative Molecular Field Analysis Studies on Agonist of Melatonin Sheep Receptors, J. Med. Chem., vol. 41, No. 23, pp. 4453-4465, 1998.
Martin, par Christian et al., Reactions Selectives de L'O.Chlorobenzonitrile : SNAr, Tetrahedron Letters, vol. 30, No. 8, pp. 935-936, 1989.
Park, Sang Sun et al., A Facile Synthesis of 2,3-Disubstituted Pyrrolo[2,3-b]pyridines via Palladium-Catalyzed Heteroannulaton with Internal Alkynes, Tetrahedron Letters, NL, Elsevier Science Publishers, vol. 39, No. 7, pp. 627-630, 1998.
Protiva, Miroslav et al., Anthistaminove latky XXVI. Nekolik novych heterocyklickych derivatu ethylendiaminu, Chem. Listy, vol. 46, pp. 551-554, 1952.
Rubtsov, M.V. et al., Preparaton of Vinylpyridines, Byulleten Izobretnii i Tovarnykh Znakor, V. 10, p. 22, 1964, Su 162535.
Vierfond, par Jean-Michel et al., Cyclisation par Amination Intramoleculaire Dane la Serie de la Pyrazine, Tetrahedron Letters, vol. 22, No. 13, pp. 1219-1222, 1981.

Affiliated with

Also associated with

Rating

Azaindoles does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Azaindoles, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Azaindoles will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3452375