Azaindole-ethylamine derivatives as nicotinic acetylcholine rece

Details Azaindole-ethylamine derivatives as nicotinic acetylcholine rece Azaindole-ethylamine derivatives as nicotinic acetylcholine rece

1998-03-31

1999-11-02

Jones, Dwayne C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546113, A01N 4342

Patent

active

059771313

ABSTRACT:
Compounds of formula I are useful in treatment of conditions associated with depletion of nicotine receptors in mammals. ##STR1##

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British Medical Bulletin (1986) vol. 42, No. 1, pp. 63-69, Elaine K. Perry, "The Cholinergic Hypothesis--Ten Years On".
Science, vol. 217, Jul. 30, 1982, Raymond T. Bartus, et al, "The Cholinergic Hypothesis of Geriatric Memory Dysfunction".
The Lancet, Mar. 26, 1971, P. White, et al, "Neocortical Cholinergic Neurons In Elderly People".
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Blanche et al., "Application of the Mercuric Acetate-edetic Acid Oxidation Method to the Synthesis of 11-aza-1,2,3,4,5,6,7,12b-octahydroindolo[2,3-a]quinolizines", Heterocycles, vol. 45, No. 1, Feb. 26, 1997, pp. 57-69.
Journal; Robinson; JACSAT; J. Amer. Chem. Soc.; 78; 1956; 1247, 1249.
La Manna et al., "Synthesis of 7-azatryptamines", Boll. Chim. Farm. 112(1), 12-21, 1973, see abstract only.
Yakhontov et al., "Azaindole derivatives. XLVII. Synthesis and pharmacological study of 3-aminoalkyl derivatives of azaindoles", Khim.-Farm. Zh. 8(11), 5-9, 1974, see abstract only.

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