Azaheterocyclylmethyl derivatives of...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S338000, C514S375000, C546S020000, C546S217000, C548S218000

Reexamination Certificate

active

06815448

ABSTRACT:

BACKGROUND OF THE INVENTION
Recent studies with the selective 5-HT
1A
antagonist WAY-100635 have confirmed a role for 5-HT
1A
receptors in learning and memory. Carli et. al. (Neuropharmacology (1999), 38(8), 1165-1173) demonstrated that WAY-100635 prevented the impairment of spatial learning caused by intrahippocampal injection of 3-[(R)-2-carboxypiperazin-4-yl]propyl-1-phosphonic acid (CPP), a competitive NMDA receptor antagonist, in a two-platform spatial discrimination task. Boast et. al. (Neurobiol. Learn. Mem. (1999), 71(3) 259-271) found that WAY-100635 significantly reduced the cognitive impairment induced by the non-competitive NMDA antagonist MK801, as determined by the performance of rats trained on a delayed nonmatching to sample radial arm maze task. Menesis et al. (Neurobiol. Learn. Mem. (1999), 71(2) 207-218) showed that post-training administration of WAY-100635 reversed the learning deficit induced by scopolamine, a cholinergic antagonist, in an autoshaping learning task. New, novel 5-HT
1A
antagonists would be useful for these and other uses.


REFERENCES:
patent: 5318988 (1994-06-01), Schohe-Loop et al.
patent: 5371094 (1994-12-01), Heine et al.
patent: 5869490 (1999-02-01), Stack
patent: 6525075 (2003-02-01), Tran et al.
patent: WO 91/13872 (1991-09-01), None
patent: WO 97/23485 (1997-07-01), None
patent: WO 98/29415 (1998-07-01), None
patent: WO 98/40386 (1998-09-01), None
Robichaud et al. (Annual reports in Medicinal Chemistry 35, Chapter 2) 2000.*
Saxena et al. (Pharmac. Ther. vol. 66, pp. 339-368, 1995).*
Carl Boast et al., Neurobiol. of Learning and Memory, 1999, 259-271, 71(3).
M. Carli et al., Neuropharmacology, 1999, 1165-1173, 38(8).
Alfredo Meneses et al., Neurobiol. of Learning and Memory, 1999, 207-218, 71(2).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Azaheterocyclylmethyl derivatives of... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Azaheterocyclylmethyl derivatives of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Azaheterocyclylmethyl derivatives of... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3362877

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.