Azacycloalkylalkanediphosphonic acids useful for treating diseas

Details Azacycloalkylalkanediphosphonic acids useful for treating diseas Azacycloalkylalkanediphosphonic acids useful for treating diseas

1988-11-07

1990-05-29

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

546 23, C07F 965, A61K 31675

Patent

active

049296060

ABSTRACT:
Azacycloalkylalkanediphosphonic acids of formula ##STR1## wherein R is an azabicycloalkyl radical that is attached by way of the aza ring member and is composed of ring systems each containing from 3 up to and including 8 members, and alk is lower alkylene, and their salts, have regulatory properties with regard to the calcium metabolism and can be used as medicaments for the treatment of diseases that can be attributed to calcium metabolism disorders. They are prepared, for example, by:
in a compound of formula ##STR2## wherein X.sub.1 is a functionally modified phosphono group and X.sub.2 is a free or functionally modified phosphono group, converting X.sub.1 and, where applicable, X.sub.2 into the free phosphono group(s).

REFERENCES:
patent: 3733270 (1973-05-01), Kerst
patent: 4503049 (1985-03-01), Biere et al.
patent: 4687767 (1987-08-01), Bosies et al.
Alder et al., Helvetica Chimica Acta, vol. 65, pp. 2405-2412, (1982).
Alder et al., J. Am. Chem. Soc., vol. 105, pp. 6712-6714, (1983).
CA 92:146905v of Japanese 79, 135,724.
Derwent Abstr. 93:181017z of Japanese 80, 89,293.
Chem. Abst. 99:22702b, of SU 1,002,300, (1983).

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