Azacyclic carboxylic acid derivatives, their preparation and use

Details Azacyclic carboxylic acid derivatives, their preparation and use Azacyclic carboxylic acid derivatives, their preparation and use

1989-05-10

1991-08-13

Ramsuer, Robert W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546214, 546212, 546221, 546225, 546227, 549474, 549476, 549481, 549484, 549488, 549 61, 549 62, 549 63, 549 65, 549 68, 549 75, 548527, 548517, 514461, 514471, 514473, 514438, 514444, 514445, 514446, 514447, 514326, 514327, 514330, 514315, 514422, A61K 31445, C07D40500, C07D30702, C07D40900

Patent

active

050396854

ABSTRACT:
Novel O-alkylated oximes of the general formula I ##STR1## wherein R.sup.1 and R.sup.2 are optionally substituted aromatic or heteroaromatic rings, R.sup.3 is hydrogen or lower alkyl, R.sup.4 is a nitrogen containing, substituted ring or an amino group carrying a substituted ring, and n and m independently are 0, 1 or 2, are potent inhibitors of GABA reuptake from the synaptic cleft.

REFERENCES:
patent: 4722930 (1988-02-01), Archibald et al.

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