Azacyclic carboxylic acid derivatives and their preparation and

Details Azacyclic carboxylic acid derivatives and their preparation and Azacyclic carboxylic acid derivatives and their preparation and

1991-12-06

1993-07-20

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514399, 514400, 514427, 514524, 514640, 546333, 548561, 5483325, 5483265, 558418, 564256, C07D21353, C07D23366, C07D20730, A61K 3144

Patent

active

052294048

ABSTRACT:
Novel O-alkylated oximes of the general formula I ##STR1## wherein R.sup.1 and R.sup.2 are optionally substituted aromatic or heteroaromatic rings, R.sup.3 is hydrogen or lower alkyl, R.sup.4 is a nitrogen containing, substituted ring or an amino group carrying a substituted ring, and n and m independently are 0, 1 or 2, are potent inhibitors of GABA re-uptake from the synaptic cleft.

REFERENCES:
patent: 4358450 (1982-11-01), Gebert
patent: 4722930 (1988-02-01), Archibald et al.
patent: 4772615 (1988-09-01), Pavia
patent: 5006560 (1991-04-01), Kreutner
patent: 5043327 (1991-08-01), Freyne
Rossi et al. "p-Dialchilaminoetilchetossimne . . . " Farma Ed. Sci XIX 688-702 (1964).

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