Azacyclic carboxylic acid derivatives and their preparation and

Details Azacyclic carboxylic acid derivatives and their preparation and Azacyclic carboxylic acid derivatives and their preparation and

1990-07-17

1993-05-25

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514317, 514326, 546193, 546207, 546208, 546210, 546227, C07D30702, C07D40500, C07D40900, A61K 31445

Patent

active

052140547

ABSTRACT:
Novel O-alkylated oximes of the general formula I ##STR1## wherein R.sup.1 and R.sup.2 are optionally substituted aromatic or heteroaromatic rings, R.sup.3 is hydrogen or lower alkyl, R.sup.4 is a nitrogen containing, substituted ring or an amino group carrying a substituted ring, and n and m independently are 0, 1 or 2, are potent inhibitors of GABA reuptake from the synaptic cleft.

REFERENCES:
patent: 4207319 (1980-06-01), Thuillier
patent: 4358450 (1982-11-01), Gebert
patent: 4722930 (1988-02-01), Archibald et al.
patent: 4772615 (1988-09-01), Pavia
patent: 5006560 (1991-04-01), Krutner
patent: 5071859 (1991-12-01), Knudsen
Racagni et al. "GABA and Endocrine Function" Adv. Biochem. Psychopharm. 42 5-6, 103-108 (1986).

Affiliated with

Also associated with

Rating

Azacyclic carboxylic acid derivatives and their preparation and does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Azacyclic carboxylic acid derivatives and their preparation and , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Azacyclic carboxylic acid derivatives and their preparation and will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-897403