Azabicyclo oxime and amine cholinergic agents and methods of tre

Details Azabicyclo oxime and amine cholinergic agents and methods of tre Azabicyclo oxime and amine cholinergic agents and methods of tre

1994-03-03

1995-11-07

Geist, Gary L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546112, C07D22102, A61K 3144

Patent

active

054648424

ABSTRACT:
Pharmaceutically useful nitrogen containing cyclic oxime and amine substituted compounds of the formulas I to XVI are disclosed (See specification for definitions of the substituents). Specifically, the compounds are 1-azabicyclo [3.2.1]oximes, 1-azabicyclo[3.3.1]oximes, 1-aza-4-oxobicyclo[3.3.1]oximes, 1-aza-4-oxobicyclo[3.2.1]oximes, and the corresponding amines wherein the heterocyclic ring contains 7 or 8 carbon atoms ##STR1##

REFERENCES:
CA 118:254725, "1--azabicyclo--3.3.1--nonan--4--one . . . ", King et al., J. Med. Chem. (1993) 36(6),683-9.
CA 108:5870, "... N--azadamantanyl . . . ", Beecham Group, JP 62077386, Apr. 9, 1987.

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