Azabicyclo compound matrix metalloprotease inhibitor and...

Details Azabicyclo compound matrix metalloprotease inhibitor and... Azabicyclo compound matrix metalloprotease inhibitor and...

2007-02-13

2007-02-13

Owens, Amelia A. (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S412000, C546S135000, C548S453000

Reexamination Certificate

active

10495370

ABSTRACT:
An azabicyclo compound (I) or a salt thereof in accordance with the present invention has an excellent inhibiting action on matrix metalloproteases (MMPs) activity, and is useful for pharmaceutical, cosmetic and skin external compositions.wherein R is H, alkyl, heteroalkyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, acyl, COOR1, carbamoyl or SO2R2(wherein R1and R2each are alkyl, heteroalkyl, aryl, heteroaryl, arylalkyl or heteroarylalkyl); X is methylene, ethylene or propylene; andis a single bond or a double bond.

REFERENCES:
patent: 0 895 988 (1999-02-01), None
patent: WO 98/08815 (1998-03-01), None
patent: WO 99/65867 (1999-12-01), None
Kaori Miyazaki et al., “Biochemistry”, vol. 68, No. 12, pp. 1791-1807 (1996).
Gary J. Fisher et al., “Nature”, vol. 379, No. 25, pp. 335-339 (1996).
Gary J. Fisher et al., “Pathophysiology of Premature Skin Aging Induced By Ultraviolet Light”, The New England Journal of Medicine, vol. 337, No. 20, pp. 1419-1428. (1997).

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