Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-02-21
2010-12-21
Seaman, D. Margaret (Department: 1625)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C548S263200
Reexamination Certificate
active
07855298
ABSTRACT:
The present invention relates to novel compounds of formula (I) or a pharmaceutically acceptable salt thereof:1.whereinG is selected from a group consisting of: phenyl, pyridyl, benzothiazolyl, indazolyl;p is an integer ranging from 0 to 5;R1is independently selected from a group consisting of: halogen, hydroxy, cyano, C1-4alkyl, haloC1-4alkyl, C1-4alkoxy, haloC1-4alkoxy, C1-4alkanoyl; or corresponds to a group R5;R2is hydrogen or C1-4alkyl;R3is C1-4alkyl;R4is hydrogen, or a phenyl group, a heterocyclyl group, a 5- or 6-membered heteroaromatic group, or a 8- to 11-membered bicyclic group, any of which groups is optionally substituted by 1, 2, 3 or 4 substituents selected from the group consisting of: halogen, cyano, C1-4alkyl, haloC1-4alkyl, C1-4alkoxy, C1-4alkanoyl;R5is a moiety selected from the group consisting of: isoxazolyl, —CH2—N -pyrrolyl, 1,1-dioxido-2-isothiazolidinyl, thienyl, thiazolyl, pyridyl, 2 -pyrrolidinonyl, and such a group is optionally substituted by one or two substituents selected from: halogen, cyano, C1-4alkyl, haloC1-4alkyl, C1-4alkoxy, C1-4alkanoyl;and when R1is chlorine and p is 1, such R1is not present in the ortho position with respect to the linking bond to the rest of the molecule; and when R1corresponds to R5, p is 1; or a salt thereof which are useful as modulators of dopamine D3receptors, e.g. to treat drug dependency or as antipsychotic agents.
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Arista Luca
Bonanomi Giorgio
Capelli Anna Maria
Damiani Federica
Di Fabio Romano
Gimmi Edward R.
Glaxo Group Limited
Kanagy James M.
Kinzig Charles M.
Seaman D. Margaret
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