Azabicyclo (3.1.0.) hexane derivatives useful as modulators...

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C548S263200

Reexamination Certificate

active

07855298

ABSTRACT:
The present invention relates to novel compounds of formula (I) or a pharmaceutically acceptable salt thereof:1.whereinG is selected from a group consisting of: phenyl, pyridyl, benzothiazolyl, indazolyl;p is an integer ranging from 0 to 5;R1is independently selected from a group consisting of: halogen, hydroxy, cyano, C1-4alkyl, haloC1-4alkyl, C1-4alkoxy, haloC1-4alkoxy, C1-4alkanoyl; or corresponds to a group R5;R2is hydrogen or C1-4alkyl;R3is C1-4alkyl;R4is hydrogen, or a phenyl group, a heterocyclyl group, a 5- or 6-membered heteroaromatic group, or a 8- to 11-membered bicyclic group, any of which groups is optionally substituted by 1, 2, 3 or 4 substituents selected from the group consisting of: halogen, cyano, C1-4alkyl, haloC1-4alkyl, C1-4alkoxy, C1-4alkanoyl;R5is a moiety selected from the group consisting of: isoxazolyl, —CH2—N -pyrrolyl, 1,1-dioxido-2-isothiazolidinyl, thienyl, thiazolyl, pyridyl, 2 -pyrrolidinonyl, and such a group is optionally substituted by one or two substituents selected from: halogen, cyano, C1-4alkyl, haloC1-4alkyl, C1-4alkoxy, C1-4alkanoyl;and when R1is chlorine and p is 1, such R1is not present in the ortho position with respect to the linking bond to the rest of the molecule; and when R1corresponds to R5, p is 1; or a salt thereof which are useful as modulators of dopamine D3receptors, e.g. to treat drug dependency or as antipsychotic agents.

REFERENCES:
patent: 2007/0249642 (2007-10-01), Bertani et al.
patent: 2008/0058398 (2008-03-01), Anderton et al.
patent: 2008/0167357 (2008-07-01), Hamprecht et al.
patent: 2008/0176917 (2008-07-01), Andreotti et al.
patent: 2008/0227837 (2008-09-01), Arista et al.
patent: 2008/0242715 (2008-10-01), Capelli et al.
patent: 2009/0030062 (2009-01-01), Gentile et al.
patent: 2009/0036461 (2009-02-01), Hamprecht et al.
patent: 2009/0124629 (2009-05-01), Bonanomi et al.
patent: 2009/0221593 (2009-09-01), Bonanomi et al.
patent: 2009/0221618 (2009-09-01), Arista et al.
patent: WO00/42037 (2000-07-01), None
patent: WO01/98267 (2001-12-01), None
patent: WO02/40471 (2002-05-01), None
patent: WO03/035622 (2003-05-01), None
U.S. Appl. No. 11/917,352, filed Jun. 13, 2006, Arista, et al.
U.S. Appl. No. 12/295,024, filed Mar. 30, 2007, Bertani, et al.
U.S. Appl. No. 12/295,304, filed Mar. 30, 2007, Bertani, et al.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Azabicyclo (3.1.0.) hexane derivatives useful as modulators... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Azabicyclo (3.1.0.) hexane derivatives useful as modulators..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Azabicyclo (3.1.0.) hexane derivatives useful as modulators... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4173532

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.