Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-08-18
2010-06-29
Padmanabhan, Sreeni (Department: 1627)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S293000, C544S242000, C544S312000, C548S245000, C548S315100, C548S331100, C548S334100
Reexamination Certificate
active
07745458
ABSTRACT:
The present invention relates to novel compounds of formula (I) or a salt thereof:wherein:p is 0, 1, 2, 3, 4 or 5;R1is independently selected from a group consisting of: halogen, hydroxy, cyano, C1-4alkyl, haloC1-4alkyl, C1-4alkoxy, haloC1-4alkoxy, C1-4alkanoyl and SF5;n is 3 or 4;R2is hydrogen or C1-4alkyl;n is 2 or 3;X is —CH2—, —O— or —S—;Z may be —CH— or N;A is a group P or P1,wherein P isand P1 isandY is hydrogen, —OH, C1-4alkyl, haloC1-4alkyl, phenyl or a heteroaromatic group, wherein the phenyl and the heteroaromatic group are optionally substituted by one or two substituents selected from a group consisting of C1-4alkyl, haloC1-4alkyl, C1-4alkoxy and haloC1-4alkoxy;processes for their preparation, intermediates used in these processes, pharmaceutical compositions containing them and their use in therapy, as modulators of dopamine D3receptors, e.g. to treat substance related disorders, as antipsychotic agents premature ejaculation or cognition impairment.
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Arista Luca
Checchia Anna
Gentile Gabriella
Hamprecht Dieter
Micheli Fabrizio
Gimmi Edward R.
Glaxo Group Limited
Kanagy James M.
Kinzig Charles M.
Padmanabhan Sreeni
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