Azabicyclic compounds with muscarinic activity useful for treati

Details Azabicyclic compounds with muscarinic activity useful for treati Azabicyclic compounds with muscarinic activity useful for treati

1990-08-02

1995-11-28

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514305, 546112, 546133, C07D45302, A61K 31435

Patent

active

054708591

ABSTRACT:
A pharmaceutical composition useful to treating dementia which comprises a compound of formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## in which p is 1 and either m is 0 and n is 2 or 3 or m is 1 and n is 2, or p is 2, m is 0 and n is 2, and Z is a heterocyclic group ##STR2## in which Q represents a 3-membered divalent residue completing a 5-membered aromatic ring and comprises one or two heteroatoms selected from oxygen, nitrogen and sulphur, or three nitrogen atoms, any amino nitrogen being substituted by a C.sub.1-2 alkyl, cyclopropyl or propargyl group, and any ring carbon atom being optionally substituted by a group R.sub.1 ; or a group ##STR3## which A.sub.1, A.sub.2 and A.sub.3 complete a 5-membered aromatic ring and A.sub.1 is oxygen or sulphur, one of A.sub.2 and A.sub.3 is CR.sub.2 and the other is nitrogen or CR.sub.3, or A.sub.2 is oxygen or sulphur, one of A.sub.1 and A.sub.3 is CR.sub.2 and the other is CR.sub.3 ; and R.sub.1, R.sub.2 and R.sub.3 are independently selected from hydrogen, halogen, N(R.sub.4).sub.2, C.sub.2-3 alkenyl, C.sub.2-3 alkynyl or C.sub.1-2 alkyl optionally substituted with one, two or three fluorine atoms, in which R.sub.4 is hydrogen or methyl, and a pharmaceutically acceptable carrier.

REFERENCES:
Journal of Organic Chemistry vol. 31, No. 9, 1966 pp. 2957-2962; F. I. Carroll et al.
Journal of Organic Chemistry vol. 34, No. 11, 1969 pp. 3674-3676, D. O. Spry et al.

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