Azabicyclic, azatricyclic and azaspirocyclic derivatives of...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C546S016000, C548S408000, C540S543000, C514S409000

Reexamination Certificate

active

11202012

ABSTRACT:
Azabicyclic, azatricyclic and azaspirocyclic derivatives of aminocyclohexanes which are systemically-active as NMDA, 5HT3, and nicotinic receptor antagonists, pharmaceutical compositions comprising the same, method of preparation thereof, and method of treating CNS disorders which involve disturbances of glutamatergic, serotoninergic, and nicotinic transmission, treating immunomodulatory disorders, and antimalaria, antitrypanosomal, anti-Borne virus, anti-HSV and anti-Hepatitis C virus activity.

REFERENCES:
patent: 5936088 (1999-08-01), Olesen
patent: 0018077 (1980-10-01), None
patent: 0072438 (1983-02-01), None
patent: 0578560 (1994-01-01), None
patent: 1153973 (1969-06-01), None
patent: 1472334 (1977-05-01), None
patent: WO 92/12149 (1992-07-01), None
patent: WO 94/08964 (1994-04-01), None
patent: WO 96/06081 (1996-02-01), None
patent: WO 00/32600 (2000-06-01), None
patent: WO 01/98253 (2001-12-01), None
R.L. Frank, H.K. Hall (1950) J. Am. Chem. Soc. 72:1645-1648.
G.A. Hiegel, P. Burk. (1973) J. Org. Chem. 38:3637-3639.
N.F. Firrell, P.W. Hickmott. (1970) J. Chem. Soc. C:716-719.
G.H. Posner, L.L. Frye. (1984) Isr. J. Chem. 24:88-92.
G.L. Lemiere, T.A. van Osselaer, F.C. Anderweireldt. (1978) Bull. Soc. Chim. Belg. 87:771-782.
H.O. House, J.M. Wilkins. (1976) J. Org. Chem. 41:(25) 4031-4033.
A.R. Greenaway, W.B. Whalley. (1976) J. Chem. Soc. P.T. 1.:1385-1389.
S. Matsuzawa, Y. Horiguchi, E. Nakamura, I. Kuwajima. (1989) Tetrahedron 45:(2) 349-362.
H.O. House, W.F. Fischer. (1968) J. Org. Chem. 33:(3) 949-956.
Chiurdoglu, G., Maquestiau, A. (1954) Bull. Soc. Chim. Belg. 63: 357-378.
Zaidlewicz, M., Uzarewicz A., Zacharewicz, W. (1964) Roczniki Chem. 38: 591-597.
Crossley, A.W., Gilling, C. (1910) J. Chem. Soc. 2218.
Zaidlewicz, M., Uzarewicz, A. (1971) Roczniki Chem. 45: 1187-1194.
Lutz, E.T., van der Maas, J.H. (1981) Spectrochim. Acta, A. 38A:283.
Lutz, E.T., van der Maas, J.H. (1981) Spectrochim. Acta, A. 37A: 129-134.
Ramalingam K., Balasubramanian, M., Baliah, V. (1972) Indian J. Chem. 10: 366-369.
Hamlin, K.E., Freifelder, M. (1953) J. Am. Chem. Soc. 75: 369-373.
Hassner, A., Fibinger, R., Andisik, D. (1984) J. Org. Chem. 49: 4237-4244.
W. Danysz, C.G. Parsons, I. Bresink, G. Quack (1995) Drug News Perspect. 8:261-277.
J.D. Leander, R.R. Lawson, P.L., Ornstein, D.M. Zimmerman (1988) Brain Res. 448:115-120.
C.G. Parsons, G. Quack, I. Bresink, L. Baran, E. Przegalinski, W. Kostowski, P. Krzascik, S. Hartmann, W. Danysz (1995). Neuropharmacology 34:1239-1258.
M.A. Rogawski (1993) Trends Pharmacol. Sci. 14:325-331.
Booher J. and Sensenbrenner M. (1972). Neurobiology 2:97-105.
Dichter, M. (1987) Brain Research 149:279.
Parsons, et al.,Drug News Perspect., Nov. 1998, 11, 523-569.
Brunson, et al.,Dev. Neurosci., 2001, 23, 31-40 (abstract).
Hadj, et al.,Neurobiol. Dis., 2004, 15, 171-176 (abstract).
Javitt,Mol. Psychiatry, 2004, [Epub ahead of print] (abstract).
Paquet-Durand, et al., 2004, 1011, 33-47 (abstract).
Hare, et al.,Invest. Ophthalmol. Vis. Sci., 2004, 45, 2625-2639 (abstract).
Rosin, et al.,J. Neurochem., 2004, 90, 1173-1185 (abstract).
Dirson, et al.,Metab. Brain Dis., 2002, 17, 77-82 (abstract).
Petri, et al.,Neurosci. Lett., 2004, 360, 170-174 (abstract).
Khodorov,Prog. Biophys. Mol. Biol., 2004, 86, 279-351 (abstract).
Tsai, et al.,Am. J. Psychiatry, 1995, 152, 332-340 (abstract).
Ferrer, et al.,Acta Neuropathol., 2003, 106, 311-318 (abstract).
Greenshaw,TiPS, 1993, 14, 265-270.
Dahlof, et al.,Cephalalgia, 1998, 18, 593-604 (abstract).
Talley,Br. J. Clin. Pharmacol., 2003, 56, 362-369 (abstract).
Deakin,Int. Clin. Psychopharmacol., 1991,6 Suppl 3, 23-31 (abstract).
Meltzer,Schizophr. Bull., 1991, 17, 263-287 (abstract).
Gbadamosi, et al.,Acta. Neurol. Scand., 2001, 104, 308-311 (abstract).
Quick, et al.,Desensitization of Neuronal Nicotinic Receptors, 2002, Wiley Periodicals, Inc., 457-478.
LLoyd, et al.,Life Sciences, 1998, 62, 1601-1606.
Mc Evoy, et al.,Curr. Drug Targets CNS Neurol. Disord., 2002, 1, 433-442 (abstract).
Newhouse, et al.,Curr. Top Med. Chem., 2004, 4, 267-282 (abstract).
Patent Abstracts of Japan, vol. 012, No. 192 (P-712), Jun. 4, 1988.
Beilstein Crossfire Database abstractAccession Nos. 5577766(brn); 5586551(brn); 5615067(brn).
Darwish, et al.,Chemical Abstracts, Accession No. 97:2169.
Chemical Abstracts Chemcats Database, Accession No. 2002:3093676.
Chemical Abstracts, Database AccessionNo. 121: 205227.
Deakin,Int. Clin. Psychopharmacol., 1991,6 Suppl 3, 23-31 (abstract).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Azabicyclic, azatricyclic and azaspirocyclic derivatives of... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Azabicyclic, azatricyclic and azaspirocyclic derivatives of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Azabicyclic, azatricyclic and azaspirocyclic derivatives of... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3792211

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.