Azaaspartic acid analogs as interleukin-1.beta. converting enzym

Details Azaaspartic acid analogs as interleukin-1.beta. converting enzym Azaaspartic acid analogs as interleukin-1.beta. converting enzym

1994-08-02

1996-10-15

Russel, Jeffrey E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514119, 514407, 514471, 514542, 514551, 514563, 514565, 5483701, 549318, 560 37, 560169, 562442, 562561, A61K 31195, A61K 3805, C07C22902, C07K 5062

Patent

active

055654304

ABSTRACT:
Disclosed are compounds, compositions and methods for inhibiting interleukinprotease activity. The compounds, .alpha.-substituted acetamides a ##STR1## wherein: R.sub.2 =H or alkyl;

REFERENCES:
patent: 5430128 (1995-07-01), Chapman et al.
patent: 5434248 (1995-07-01), Chapman et al.
Bioorg. Med. Chem. Lett., vol. 2, No. 6, issued 1992, Chapman, "Synthesis of a Potent, Reversible Inhibitor . . . ", pp. 613-618.
Chem. Ber., vol. 102, issued 1969, Niedrich, "Synthese von substituierten 2.4-Bis . . . ", pp. 1557-1569.
Tet. Letters, vol. 26, No. 26, issued 1985, Moody et al, "Synthesis of Aza-.beta.-Lactams by Rhodium . . . ", pp. 3171-3172.
Chemical Abstracts 78: 72578c (1973).
Chemical Abstracts 88:38140a (1978).

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