Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1996-01-18
1998-12-22
Rotman, Alan L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546 16, 546 19, 546 20, C07D49110, C07D49120, A61K 31445, A61K 3146
Patent
active
058520295
ABSTRACT:
Compounds useful for treating diseases of the central or peripheral nervous system in mammals have formulae I-XII ##STR1## wherein ring A or A' together with the spiro-carbon atom constitutes a bridged or unbridged ring containing one or two ring nitrogen atoms; and the other symbols have specified values, subject to certain conditions.
REFERENCES:
patent: 3161644 (1964-12-01), Beilstein
patent: 3629276 (1971-12-01), Harnden
patent: 3717634 (1973-02-01), Wu et al.
patent: 3784551 (1974-01-01), Nakaniski et al.
patent: 3792053 (1974-02-01), Potoski et al.
patent: 3850949 (1974-11-01), Ono et al.
patent: 4083985 (1978-04-01), Cohen et al.
patent: 4104397 (1978-08-01), Cohen et al.
patent: 4735944 (1988-04-01), Bollinger
patent: 4746655 (1988-05-01), Cale, Jr.
patent: 4855290 (1989-08-01), Fisher et al.
patent: 4900830 (1990-02-01), Fisher et al.
patent: 4981858 (1991-01-01), Fisher et al.
patent: 5073560 (1991-12-01), Wu et al.
patent: 5534520 (1996-07-01), Fisher et al.
Chemical Abstracts 119: 16165 m, Oct. 11, 1993.
Chemical Abstracts 119: 101570f, Aug. 1993.
Chemical Abstracts 119: 101573j, Aug. 1993.
Chemical Abstracts 119: 140115j, Sep. 27, 1993.
Chemical Abstracts 114: 164201q, Apr. 29, 1991.
Chemical Abstracts 110: 114821p, Mar. 27, 1989.
Chemical Abstracts 110: 140112f, Apr. 17, 1989.
Chemical Abstracts 110: 140094y, Apr. 17, 1989.
Chemical Abstracts 110: 140152u, Apr. 17, 1989.
Chemical Abstracts 110: 101632c: Mar. 20, 1989. Chem. 1992, 35, 1541-1550.
Abstract of TW 201312 (State of Israel Inst. Biol. Res.) Mar. 1, 1993.
J.Med.Chem. vol. 30, 1987, Washington, pp. 969-975, Saunders, J.Et al. "Synthesis and Charactersiation of all four isomers".
J.Med.Chem. vol. 31, 1988, Washington, pp. 486-491 Saunders, J.etal. Agonsits".
J.Med.Chem. vol. 35, 1992, Washington, pp. 1541-1550; Nordvall,G.et al. "Analogues ofthe Muscarinic Agent".
Chem. Abstracts, vol. 71(91), 91359-d, Nov. 10, 1969.
Chem. Abstracts, vol. 73(19), 98869-V, Nov. 9, 1970.
Chem. Abstracts, vol. 97(17), 144165H, Oct. 25, 1982.
Chem. Abstracts, vol. 109(3) 16597-e, Jul. 18, 1988.
Trigo et al., Journal of Heterocyclic Chemistry, vol. 21, No. 5, pp. 1479-83, Sep.-Oct. 1984.
E. Galvez, et al., Synthesis and Structural Study of cyclopenatne, Indene and Fluorene Spiro-derivatives, Journal of Heterocyclic Chemistry, 20, 13, 1983.
P.L. Feldman, et al., A Novel route to the Class of Analgetics Journal of Organic Chemistry, 55, 4207-4209, 1990.
Y. Ishihara, et al., Central Cholinergic Agemts. III. Synthesis of Chem. Pharm. Bull., 40(5), 1177-1185, 1992.
G.G. Trigo, et al., Synthesis ans Structural Study of Quinuclidine Spiro Derivatives, Journal of Heterocyclic Chemistry, 18, 1507-1511 ,1981.
M.V. Garcia, et al., Study of the Reaction Between Cyanohydrin and Chlorosulfonyl Isocyanate. A New, Efficient Method for the One-Pot Synthesis of 2,4-Oxazolidinediones, Synthesis, 1991.
A. Jossang, et al. Horsfiline, an Oxindole Alkaloid from Horsfieldia superba, Journal of Organic Chemistry, 56, 6527-6530, 1991.
G.M. Carrera, Jr., et al., Synthesis of Novel Substituted Spirohydantoins, Jornal of Heterocyclic Chemistry, 29, 847-85 1992.
G.G. Trigo, et al., PMR and 13C-NMR Spectroscopy of Tropane an N-Substituted Nortopane Spirohydantoins, Journal of Pharmaceutical Sciences, 70(1), 87-89, 1981.
L.G. Wade,Jr. Organic Chemistry, p. 349, Prentice-Hall Publishers, 1987.
Barak Dov
Fisher Abraham
Karton Yishal
Marciano Daniele
Meshulam Haim
Israel Institute for Biological Research
Rotman Alan L.
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