Aza spiro alkane derivatives as inhibitors of metalloproteases

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C514S276000, C514S278000, C514S290000, C544S344000, C544S360000, C546S019000, C546S247000

Reexamination Certificate

active

08039471

ABSTRACT:
The present invention provides a compound of Formula I or Formula II:enantiomer, diastereomer, prodrug, solvate, metabolite, or pharmaceutically acceptable salt thereof, wherein constituent variables are provided herein. The compounds of Formula I and II are modulators of metalloproteases and are useful in treating diseases associated with metalloprotease activity such as arthritis, cancer, cardiovascular disorders, skin disorders, inflammation and allergic conditions.

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