Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2011-04-19
2011-04-19
Wilson, James O (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C544S236000
Reexamination Certificate
active
07928106
ABSTRACT:
The invention is concerned with novel aza-pyridopyrimidinone derivatives of formula (I):wherein R1, R2, R3, R4, R5, X1, X2, X3, Y, Z, m and n are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds are HM74A agonists and can be used in treating or preventing diseases which are modulated by HM74A agonists.
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Wolff et. al., “Burger's Medicinal Chemistry and Drug Discovery,” 5th Ed. Part 1, pp. 975-977 (1995).
Banker, et. al., Modern Pharmaceuticals, (1996) p. 596-7.
Abarca et al., Tetrahedron, 45, pp. 7041-7048 (1989).
Zumbrunn et al., Synthetic Communications, 28, pp. 475-483 (1998).
Ferrand, G et al,Euro. Jour. of Medicinal Chem., 31:4 (1996) 273-280 XP004040087.
Conte Aurelia
Dehmlow Henrietta
Grether Uwe
Kratochwil Nicole A.
Kuehne Holger
Hoffmann-La Roche Inc.
Johnston George W.
Murray Jeffrey H
Remy Brian C.
Tramaloni Dennis P.
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