Aza-peptide epoxides

Details Aza-peptide epoxides Aza-peptide epoxides

2006-06-06

2006-06-06

Lambkin, Deborah C. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C549S548000

Reexamination Certificate

active

07056947

ABSTRACT:
The present invention provides compositions for inhibiting proteases, methods for synthesizing the compositions, and methods of using the disclosed protease inhibitors. Aspects of the invention include aza-peptide epoxide compositions that inhibit proteases, for example cysteine proteases, either in vivo or in vitro. The disclosed compounds, pharmaceutically acceptable salts, pharmaceutically acceptable derivatives, prodrugs, or combinations thereof can be used to treat disease or pathological conditions related to the activity of proteases associated with a specific disease or condition. Such treatable conditions include viral infections, stroke, neurodegenerative disease, and inflammatory disease, among others.

REFERENCES:
patent: 5770732 (1998-06-01), Hirschmann et al.
patent: 5998470 (1999-12-01), Halbert et al.
patent: 6331542 (2001-12-01), Carr et al.
patent: 6376468 (2002-04-01), Overkleeft et al.
patent: 6387908 (2002-05-01), Nomura et al.
patent: 6462078 (2002-10-01), Ono et al.
patent: 6479676 (2002-11-01), Wolf
patent: 6586466 (2003-07-01), Yamashita
patent: 6689765 (2004-02-01), Baroudy et al.
patent: 6831099 (2004-12-01), Crews et al.
Kidwai et al, CA 125: 33462, 1996.

Affiliated with

Also associated with

Rating

Aza-peptide epoxides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Aza-peptide epoxides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Aza-peptide epoxides will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3676058