Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...
Patent
1982-06-11
1984-02-14
Rizzo, Nicholas S.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Parasitic organism or component thereof or substance...
2602452R, 2602453, A61K 31415, C07D23302
Patent
active
044316585
ABSTRACT:
Described is a novel process for the preparation of penems and carbapenems useful as antibacterial agents which comprises the reaction of an appropriate 4-substituted-azetidine-2-one with an acid halide in the presence of a tertiary amine and an alkaline earth metal carbonate, followed by reaction of the thereby formed 1-imido-4-substituted-azetidine-2-one with a trialkyl phosphite.
Also described are novel penems useful as antibacterials which are prepared by the described process.
REFERENCES:
patent: 4283531 (1981-08-01), Ganguly et al.
Afonso Adriano
Hon Frank
Eisen Bruce M.
Magatti Anita W.
Rizzo Nicholas S.
Rosen Gerald S.
Schering Corporation
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