Aza-indolyl compounds and methods of use

Details Aza-indolyl compounds and methods of use Aza-indolyl compounds and methods of use

2007-11-29

2010-12-21

Wilson, James O (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S248000, C514S265100, C544S235000, C544S253000, C546S113000

Reexamination Certificate

active

07855216

ABSTRACT:
The invention relates to azaindolyl compounds of Formula I with anti-cancer and/or anti-inflammatory activity and more specifically to azaindolyl compounds which inhibit MEK kinase activity. The invention provides compositions and methods useful for inhibiting abnormal cell growth or treating a hyperproliferative disorder, or treating an inflammatory disease in a mammal. The invention also relates to methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.

REFERENCES:
patent: 2005/0058481 (2005-03-01), Christiansen et al.
patent: 2009/0181941 (2009-07-01), Leblanc et al.
patent: WO03/091215 (2003-11-01), None
patent: WO2005/023251 (2005-03-01), None
patent: WO 2006/002051 (2006-01-01), None
patent: WO 2006/100095 (2006-03-01), None
patent: WO 2007/070393 (2007-06-01), None
Kanth, et al., Heterocycles (2005), 65(6), 1415-1423.

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