Aza hydroxylated ethyl amine compounds

Details Aza hydroxylated ethyl amine compounds Aza hydroxylated ethyl amine compounds

2005-11-01

2005-11-01

Kumar, Shailendra (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C548S190000, C548S193000, C548S194000, C548S196000, C548S200000

Reexamination Certificate

active

06960664

ABSTRACT:
Disclosed are compounds of formula:and pharmaceutically acceptable salts and esters thereof, useful in treating and/or preventing Alzheimer's disease and other similar diseases, wherein RN, RC, R1, R2and R20are defined herein. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.

REFERENCES:
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patent: WO 99 36404 (1999-07-01), None
patent: WO 02 002506 (2002-01-01), None
U.S. Appl. No. 09/895,871, Fang et al., filed Jun. 29, 2001.
U.S. Appl. No. 09/895,843, Beck et al., filed Jun. 29, 2001.
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U.S. Appl. No. 10/152,601, Schostarez et al., filed May 22, 2002.
U.S. Appl. No. 10/291,318, Varghese et al., filed Nov. 8, 2002.

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