Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1994-10-31
1996-05-14
Chan, Christina Y.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 9, 514 2, 530317, 530318, 530321, 930270, 930DIG548, 930DIG546, A61K 3812, C07K 752
Patent
active
055167560
ABSTRACT:
The present invention is directed to novel aza cyclohexapeptide compounds of the formula ##STR1## where all substituents are defined herein, which are useful as antifungal agents and for the treatment of Pneumocystis carinii infections. Compositions containing the compounds of the invention are also disclosed.
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patent: 5202309 (1993-04-01), Schwartz et al.
patent: 5378804 (1995-01-01), Balkovec et al.
Zanblas, Journal of Medicinal Chemistry, vol. 35, pp. 2843-2855 (1992).
Walzer, . . . "Pneumocystis Carinii--New Clinical Spectrum . . . " NEJM; 324, No. 4, pp. 263-265, Jan. 24, 1991.
Bartlett, et al.,, . . . "Pneumocystis Carinii, An Opportunist . . . " Clinical Microbiology Reviews; 4, No. 2, pp. 137-149, Apr. 1991.
Schwartz, et al., J. Antibiotics; 45 No. 12, pp. 1853-1866 (1992).
Walzer, et al., Diagn. Microbiol. Infect. Dis.; 21, pp. 1-6, 1984.
Balkovec James M.
Bouffard Frances A.
Dropinski James F.
Chan Christina Y.
Daniel Mark R.
Korsen Elliott
Merck & Co. , Inc.
Wessendorf T. D.
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