Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1987-06-26
1989-09-26
Fan, Jane T.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514216, 514413, 546112, 546183, 540581, 548453, C07D22122, A61K 3145
Patent
active
048700819
ABSTRACT:
A compound of formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## in which A represents a bond or --CH.sub.2 -- and B represents hydrogen, or A and B together with the carbon atom to which they are both attached represents a group ##STR2## R represents R.sub.1 OOC-- in which R.sub.1 is C.sub.1-4 alkyl, C.sub.2-4 alkenyl or C.sub.2-4 alkynyl; R.sub.2 O-- in which R.sub.2 is C.sub.1-3 alkyl, C.sub.1-2 alkylcarbonyl or aminocarbonyl optionally substituted by one or two methyl groups; or R.sub.3 CH.sub.2 - in which R.sub.3 is C.sub.1-2 alkoxy; and p represents an integer of 2 to 4, and wherein compounds of formula (I) where B is hydrogen have the stereochemical configuration in which the group R and the methylene bridge are both on the same side of the plane of the molecule which contains both bridge head atoms and the ring carbon atom bonded to the group R.
REFERENCES:
patent: 2658067 (1953-11-01), Duschinsky
patent: 3501471 (1970-03-01), Remers et al.
patent: 3681363 (1972-08-01), Elkin et al.
patent: 4038402 (1977-07-01), Kaminka et al.
patent: 4203990 (1980-05-01), Yen
Home Medical Encyclopedia, vol. 1, p. 158.
Brian Richardson et al., CA 104:19506g.
H. S. Aaron et al., J. Amer. Chem. Soc., 89, pp. 1431-1437 (1967).
G. Lambrecht and E. Mutschler, Drug Res., 24, p. 1725 (1974).
C. A. Grob and E. Renk, Helv. Chim. Acta., 37, p. 1689 (1954).
M. J. Martell and T. O. Soine, J. Pharm. Sci., 52, pp. 331-336 (1963).
M. D. Mashkovsky, Proc. 1st Int. Pharmacol. Meet., 7, p. 359 (1963).
D. Spry and H. S. Aaron, J. Org. Chem., 84, pp. 3674-3676 (1969).
L. H. Sternbach and S. Kaiser, J. Amer. Chem. Soc., 74, pp. 2219-2221 (1952) ("Sternbach-I").
L. H. Sternbach and S. Kaiser, J. Amer. Chem. Soc., 74, pp. 2215-2218 (1952) ("Sternbach-II").
Hadley Michael S.
Orlek Barry S.
Rosenberg Howard E.
Wadsworth Harry J.
Barr David K.
Beecham Group p.l.c.
Fan Jane T.
Haley, Jr. James F.
Solomon Teresa L.
LandOfFree
Aza-bicyclic compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Aza-bicyclic compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Aza-bicyclic compounds will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-187915