Aza-benzazolium containing cyanine dyes

Details Aza-benzazolium containing cyanine dyes Aza-benzazolium containing cyanine dyes

2007-06-05

2007-06-05

Fredman, Jeffrey (Department: 1637)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S004000, C435S029000, C435S034000, C435S091200, C436S800000, C546S016000, C546S165000, C546S270100, C546S271100

Reexamination Certificate

active

10683753

ABSTRACT:
Unsymmetrical cyanine dyes that incorporate an aza-benzazolium ring moiety are described, including cyanine dyes substituted by a cationic side chain, monomeric and dimeric cyanine dyes, chemically reactive cyanine dyes, and conjugates of cyanine dyes. The subject dyes are virtually non-fluorescent when diluted in aqueous solution, but exhibit bright fluorescence when associated with nucleic acid polymers such as DNA or RNA, or when associated with detergent-complexed proteins. A variety of applications are described for detection and quantitation of nucleic acids and detergent-complexed proteins in a variety of samples, including solutions, electrophoretic gels, cells, and microorganisms.

REFERENCES:
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patent: 5221518 (1993-06-01), Mills
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patent: 6083699 (2000-07-01), Leushner et al.
patent: 05-287209 (1993-05-01), None
Translation of JP05-287209.
Haugland, R. P. (2002).Handbook of Fluorescent Probes and Research Productsand CD-ROM Supplement.

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