Aza-amino acid derivatives (factor Xa inhibitors 15)

Details Aza-amino acid derivatives (factor Xa inhibitors 15) Aza-amino acid derivatives (factor Xa inhibitors 15)

2005-02-01

2005-02-01

Powers, Fiona T. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S327000, C514S357000, C514S381000, C514S467000, C514S482000, C514S507000, C514S562000, C514S590000, C544S159000, C546S222000, C546S332000, C548S253000, C549S229000, C560S013000, C560S024000, C560S029000, C560S129000, C560S251000

Reexamination Certificate

active

06849626

ABSTRACT:
The invention relates to semicarbazides of the general formula Iwhere R1, R2, R3, R4and I have the meaning indicated in claim1.The compounds of the formula I can be employed as pharmaceutical active compounds in human and veterinary medicine, in particular for the control and prevention of thromboembolic disorders such as thrombosis, mycocardial infarct, arteriosclerosis, inflammation, apoplexy, angina pectoris, restenosis after angioplasty and intermittent claudication.

REFERENCES:
patent: 3285957 (1966-11-01), Raymond et al.
patent: 1020434 (2000-07-01), None
J.M. Fevig, et al, “Preparation of Meta-amidino-N,N-disubstituted Anilines as Potent Inhibitors of Coagulation Factor Xa,” Bioorganic and Medical Chemistry Letters, Nov. 17, 1998, pp. 3143-3148, vol. 8, no. 22, XP004143716, ISSN: 0960-894X, table 1, Elsevier Science Publishers, Amsterdam, NL.

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