Aza-5,5-fused hetrocyclic acids as leukotriene antagonists

Details Aza-5,5-fused hetrocyclic acids as leukotriene antagonists Aza-5,5-fused hetrocyclic acids as leukotriene antagonists

1993-08-04

1994-09-27

Brust, Joseph Paul

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514375, 548153, 548218, C07D51304, C07D49804, A61K 3142, A61K 31425

Patent

active

053507606

ABSTRACT:
Compounds having the formula I: ##STR1## are antagonists of the actions of leukotrienes. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis, and allograft rejection.

REFERENCES:
patent: 4794188 (1988-12-01), Musser et al.
patent: 5037840 (1991-08-01), Young et al.

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