Axl kinase inhibitors

Details Axl kinase inhibitors Axl kinase inhibitors

2011-08-16

2011-08-16

Moore, Susanna (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C544S280000, C514S252160

Reexamination Certificate

active

07998966

ABSTRACT:
Axl kinase inhibitory compounds are disclosed, as well as compositions and methods of using the same in the treatment of cancer and other conditions mediated by and/or associated with Axl kinase.

REFERENCES:
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patent: 2007/020888 (2007-02-01), None
patent: 2004/058772 (2007-07-01), None
patent: 2008/055233 (2008-05-01), None
Matsuno et al., “Potent and Selective Inhibitors of Platelet-Derived Growth Factor Receptor Phosphorylation. 1. Synthesis, Structure—Activity Relationship, and Biological Effects of a New Class of Quinazoline Derivatives,” Journal of Medicinal Chemistry 45(14): 3057-3066, Jul. 4, 2002.
Robertson et al., “A Comparison of the Requirements for Antitumour Activity and Antibacteriophage Lambda Activity for a Series of Non-intercalative DNA-binding Agents,” European Journal of Cancer and Clinical Oncology 18(3): 271-279, Mar. 1, 1982.
Singh et al., “Chemotherapy of Filariasis—On the Search of New Agents Effective on the Reproductive System of Female Adult Worms,” Zeitschrift Fuer Naturforschung, Section C, Biosciences 45(11/12): 1210-1214, Jan. 1, 1990.
Warner et al., “Identification of a lead small-molecule inhibitor of the Aurora kinases using a structure-assisted, fragment-based approach,” Molecular Cancer Therapeutics 5(7): 1764-1773, Jul. 1, 2006.

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