Chemistry: analytical and immunological testing – Pregnancy or ovulation
Patent
1989-08-07
1990-06-05
Richman, Barry S.
Chemistry: analytical and immunological testing
Pregnancy or ovulation
128736, 128738, 436 97, 436906, G01N 3348
Patent
active
049314033
ABSTRACT:
A novel method of determining the onset of the fertile period of a human female is disclosed comprising the step of monitoring the axillary secretions of said female during the course of her menstrual cycle to determine variations in the concentration of androstenol or dehydroepiandrosterone sulfate. A first significant increase in the concentration of either of those compounds following the cessation of menses is indicative of the onset of the fertile period. In each case, a follicular phase peak occurs which exceeds by at least twice the concentration of those compounds present at any other time during the menstrual cycle. As a result, the monitoring of these compounds may act as reliable indicators predicting the occurrence of ovulation in five to seven days, and/or indicating the onset of the fertile period at a time when appropriate contraceptive measures can still be taken to avoid pregnancy or sexual intercourse can promote fertility.
REFERENCES:
patent: 3986494 (1976-10-01), Preti et al.
patent: 4010738 (1977-03-01), Preti et al.
patent: 4036212 (1977-07-01), Karuhn
patent: 4119089 (1978-10-01), Preti et al.
patent: 4385125 (1983-05-01), Preti et al.
Aedo et al., "Studies of the Pattern of Circulating Steroids in the Normal Menstral Cycle," Acta Endocrinol, 84(2), 320-332, 1977.
Frolich et al., "Serum Levels of Unconjugated Aetiocholanolone, and Androstenedione, Testosterone, Dehydroepiandrosterone, Aldosterone, Progesterone and Oestrogens During Normal Menstrual Cycle," Acta Endocrinol, 81(3), 548-562, 1976.
Rance et al., "A Preovulatory Rise of Dehydroepiandrosterone in the Mare Measured by Radioimmunoassay," J. Steroid Biochem., 7(9), 677-681, 1976.
R. F. Vollman, "The Degree of Variability of the Length of the Menstrual Cycle in Correlation with Age of Woman", Gynaecologia 142(5):310-314 (Nov. 1956).
M. K. McClintock, "Pheromonal Regulation of the Ovarian Cycle: Enhancement, Suppression and Synchrony", Pheromones and Reproduction in Mammals, Edited by J. G. Vandenbergh New York, Academic Press, pp. 113-149 (1983).
M. K. McClintock, "Estrous Synchrony: Modulation of Ovarian Cycle Length by Female Pheromones", Physiol. Behav., 32:701-705 (1984).
M. K. Izard, "Pheromones and Reproduction in Domestic Animals", Pheromones and Reproduction in Mammals, edited by J. G. Vandenbergh New York, Academic Press, pp. 253-281 (1983).
Izard et al, "Priming Pheromones From Oestrous Cows Increase Synchronization of Oestrus in Dairy Heifers After PGF-2.alpha.Injection", Reproduction Fertility, 66:189-196 (1982).
M. K. McClintock, "Menstrual Synchrony and Suppression", Nature, 229:244-245 (Jan. 22, 1971).
C. A. Graham et al. "Menstrual Synchrony in Female Undergraduates Living on a Coeductional Campus", Psychoneuroendocrinology, 5:245-252 (1980).
Rogel, "A Critical Evaluation of the Possibility of Higher Primate Reproductive and Sexual Pheromones", Psychol. Bull. 85:810-830, (1978).
D. M. Quadagno, "Influence of Male Social Contacts, Exercise and All-Female Living Conditions on the Menstrual Cycle", Psychoneuroendrocrinology, 6:239-244 (1981).
J. L. Veith et al., "Exposure to Men Influences in the Occurrence of Ovulation in Women", Physiology & Behavior, 31:313-315 (1983).
Russell et al "Olfactory Influences on the Human Menstrual Cycle", Pharmac. Biochem. Behav., 13(5):1-2 (1980).
J. N. Labows, "Human Odors--What Can They Tell Us?", Perfumer and Flavorist, 4:12-17 (1979).
J. J. Leyden et al. "The Microbiology of the Human Axilla and Its Relation to Axillary Odors", J. Invest. Dermatol. 77:413-416 (1981).
S. Bird et al., "Axillary 5.alpha.androst-16-en-3-one, Cholesterol and Squalene in Men; Preliminary Evidence for 5.alpha.androst-16-3n-3-one Being a Product of Bacterial Action", J. Steroid Biochem., 17:517-522 (1982).
S. Bird et al., "Measurement of 5.alpha.androst-16-en-one in Human Axillary Secretions by Radioimmunoassay", J. Endrocrinol., 85: 80-90.
B. W. L. Brooksbank et al., "The Detection of 5.alpha.androst-16-en-3.alpha.ol in Human Male Axillary Sweat", Experientia, 30:864-865 (1974).
R. V. Vollman, The Menstrual Cycle, vol. 7, (Major Problems in Obstetrics and Gynecology), edited by Emmanuel Friedman, M.D.
A. E. Treloar, "Variation of the Human Menstrual Cycle Through Reproductive Life", Internl Journl of Fert., 12(1):77-126 (1967).
Clark et al., "Human Responses to Scent-Marking with the Putative Pheromone Androstenone" (unpublished manuscript) (1978).
W. Cutler, "Lunar and Menstrual Phase Locking", American Journal of Obstetrics and Gynecology, 137:834 (1980).
W. Cutler et al, "Infertility and Age at First Coitus: A Possible Relationship", J. Biosoc. Sc., 11:425-432 (1979).
W. Cutler et al., "Sexual Behavior Frequency and Menstrual Cycle Length in Mature Premenopausal Women", Psychoneuroendocrinology, 4:297-309 (1979).
W. Cutler et al, "Luteal Phase Defects: A Possible Relationship Between Short Hyperthermic Phase and Sporadic Sexual Behavior in Women", Hormones and Behavior, 13:214-218 (1979).
W. Cutler et al, "Sporadic Sexual Behavior and Menstrual Cycle Length in Women", Hormones and Behavior, 14:163-172 (1980).
W. Cutler et al., "The Psychoneuroendocrinology of the Ovulatory Cycle of Woman: A Review", Psychoneuroendocrinology, 5:89 (1980).
W. Cutler et al., "Sexual Behavior, Steroids & Hot Flashes are Associated During the Perimenopause", Neuroendocrinology Letters, 5:185 (1983).
J. N. Labows et al., "Steroid Analysis of Human Apocrine Secretion", Steroids, 34:249-258 (1979).
G. Preti et al., "Cyclic Changes in Volatile Acidic Metabolites of Human Vaginal Secretions and Their Relationships to Ovulation", J. Chem. Ecol, 1:361-376 (1975).
Abstract presented at the CRB Conference on Reproductive Behavior Jun. 10-12, 1984 at the University of Pittsburgh, entitled "Sex Frequency and Human Axillary Secretion Influence Fertile-Type Menstrual Cycles".
"Male Extract and Heterosexual Behavior Normalize the Menstrual Cycle of Women", Abstract, International Academy of Sex Cambridge, England (Sep. 1984), Cutler et al.
A. R. Genazzani et al., "Possible Correlation Between Plasma Androgen Variations During the Menstrual Cycle and Sexual Behavior in the Human Female", Chemical Abstracts, vol. 91, 1978, Abstract No. 91:121339e, Proc. Serono Symp. 22 (Clin. Psychoneuroendo. Reprod. 419-435.
N. McCoy et al., "Relationships Among Sexual Behavior, Hot Flashes, and Hormone Levels in Perimenopausal Women", Archives of Sexual Behavior, 14(5):385-394 (1985).
Cutler et al., "The Medical Management of Menopause and Premenopause", Chapter 3, J. B. Lippincott Company, pp. 92-121 (1984).
"New Nose to Aid Fertility", Daily News, Aug. 14, 1984.
Bahn, Basic Medical Statistics, Chapter 8, "Review of the Decision Making Process; the Error Risks", p. 86, (1972) Grune & Stratton, Inc.
Lee and Boot, Acta Physiol. Pharmacol., Neerl, 5:213 (1956).
Cutler et al, "Sexual Behavior and Steroid Levels Among Gynecologically Mature Premenopausal Women", Fertil. & Steril, Apr. 1986.
Cutler et al., "Perimenopausal Sexuality", Archives of Sexual Behavior (in press).
C. C. Norris, "The Menopause", American Journal of Obstet., 41:203-215 (1910).
Metcalf, "Incidence of Ovulatory Cycles in Women Approaching the Menopause", Journal of Biosoc. Sci., 11:39-48 (1979).
Rutherford, "The Menopause", N.Z. Med. J., 87:251-253 (1978).
Kupperman et al., "Contemporary Theory of the Menopausal Syndrome", JAMA, 171:1627-1637 (1959).
McCoy et al., "A Longitudinal Study of the Effects of Menopause on Sexuality", Maturitas 7:203-210 (1985).
Treloar, "Menstrual Cyclicity and the Premenopause", Maturitas, 3:249-264 (1981).
Cutler, et al., "Sexual Behavior Frequency and Biphasic Ovulatory Type Menstrual Cycles", Physiology & Behavior, 34:805-810 (1985).
Cutler, et al., "Human Axillary Secretions Influence Women's Menstrual Cycles: The Role of Donor Extract from Men", Hormones and Behavior, 20:463-473 (1986).
Preti, et al., "Human Axillary Secretions Influence Women's Menstrual Cycles: The Role of Donor Extract of Females", Hormones and Behavior, 20:474-482 (1986).
Cutler Winnifred B.
Huggins George R.
Preti George
McMahon Timothy M.
Monell Chemical Senses Center
Richman Barry S.
University of Pa.
LandOfFree
Axillary androstenol and dehydroepiandrosterone as fertile perio does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Axillary androstenol and dehydroepiandrosterone as fertile perio, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Axillary androstenol and dehydroepiandrosterone as fertile perio will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-491439