Avrainvillamide, a cytotoxic marine natural product, and derivat

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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514247, 514248, 514249, 544339, 544358, A61K 314985, A61K 314995, C07D24100

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active

060666358

ABSTRACT:
The present invention provides a compound having the structure ##STR1## wherein, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are independently selected from H, alkyl, aminoalkyl, perfluoroalkyl, or
pharmaceutically acceptable salts thereof, useful for treating cancer.

REFERENCES:
patent: 5473057 (1995-12-01), Fenical et al.
Fenical et al., J. Amer. Chem. Soc., 113 (6) 2303-4 (A65), 1991.
Atherton and Shephard, Solid Phase Peptide Synthesis--A Practical Approach, IRL Press, Oxford England, (1989).
Bodanzsky, Principles of Peptide Synthesis, 1.sup.st Revised Edition, Springer-Verlag, N.Y., (1984).
Bodanzsky, Principles of Peptide Synthesis, 2.sup.nd Revised Edition, Springer-Verlag, N.Y., (1984).
Greene and Wuts, Protective Groups in Organic Synthesis, Second edition, John Wiley and Sons, New York, Chapters 2, 3, and 7, (1991).
Reese and Haslam, Protective Groups in Organic Chemistry, McOmie, Plenum Press, New York NY, Chapters 3 and 4, (1973).
Stewart and Young, Solid Phase Peptide Synthesis, 2.sup.nd Edition, W.H. Freeman & Company, San Francisco (1984).

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