Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus
Patent
1991-11-07
1994-03-15
Low, Christopher S. F.
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Genetically modified micro-organism, cell, or virus
424 93R, 424 93D, 424 93P, 4351723, 4353201, 4352523, 43525233, 435879, 935 60, 935 62, 935 72, A61K 39112, C12N 121
Patent
active
052944417
ABSTRACT:
This invention provides immunogenic compositions for the immunization of a vertebrate or invertebrate comprising an avirulent derivative of S. typhi. The derivatives having a mutation of the cya and/or crp and/or cdt genes. The invention also provides immunogenic compositions for the immunization of a vertebrate and invertebrate comprising an avirulent derivative of the above type which is capable of expressing a recombinant gene derived from a pathogen of said vertebrate or invertebrate individual to produce an antigen capable of inducing an immune response against said pathogen. Other embodiments of the invention include methods of preparing immunogenic compositions from these strains, and strains useful in the preparation of the immunogenic compositions, as well as methods of stimulating the immune system to respond to an immunogenic antigen of S. typhi by administration of the immunogenic composition.
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Komeda et al. 1975. Molec. Gen. Genet. 142, 289-298.
Curtis III et al. 1987. Infec. and Immun. 55, 3055-3043.
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Ferrari et al. 1985. Bio/Technol. 3, 1003-1007.
Jagusztyn-Krynicka et al. 1982 J. Gen. Microbiol. 128, 1135-1145.
Low Christopher S. F.
Washington University
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