Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1993-07-07
1995-02-07
Low, Christopher S. F.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
4242581, 4351723, 4353201, 4352523, 43525233, 435879, 935 60, 935 62, 935 72, A61K 39112, C12N 121
Patent
active
053877446
ABSTRACT:
This invention provides immunogenic compositions for the immunization of a vertebrate or invertebrate comprising an avirulent derivative of S. typhi. The derivatives having a mutation of the cya and/or crp and/or cdt genes. The invention also provides immunogenic compositions for the immunization of a vertebrate and invertebrate comprising an avirulent derivative of the above type which is capable of expressing a recombinant gene derived from a pathogen of said vertebrate or invertebrate individual to produce an antigen capable of inducing an immune response against said pathogen. Other embodiments of the invention include methods of preparing immunogenic compositions from these strains, and strains useful in the preparation of the immunogenic compositions, as well as methods of stimulating the immune system to respond to an immunogenic antigen of S. typhi by administration of the immunogenic composition.
REFERENCES:
patent: 4190495 (1980-02-01), Curtis, III
patent: 4837151 (1989-06-01), Stocker
patent: 4888170 (1989-12-01), Curtiss, III
patent: 5294441 (1994-03-01), Curtiss, III
Curtiss III et al. 1987. Infect. Immun. 55, 3035-3043.
Komeda et al. 1975. Molec. Gen. Genet. 142, 289-298.
Ferrari et al. 1985 Bio/Technol. 3, 1003-1007.
Jagusztyn-Krynicka et al. 1982. J. Gen. Microbiol. 128, 1135-1145.
Curtiss III Roy
Kelly Sandra M.
Low Christopher S. F.
Washington University
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