Avirulent microbes and uses therefor

Details Avirulent microbes and uses therefor Avirulent microbes and uses therefor

1993-02-18

1995-11-21

Sidberry, Hazel F.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

4242001, 424 931, 424 932, 435 691, 435 711, 4351721, 4352523, 43525233, 4352528, A61K 3900, A61K 3902, C12N 121, C12N 1500

Patent

active

054684854

ABSTRACT:
This invention provides a vaccine for the immunization of a vertebrate or invertebrate comprising an avirulent derivative of S. choleraesuis. The derivatives being substantially incapable of producing functional adenylate cyclase and/or cyclic AMP receptor protein. The invention also provides a vaccine for the immunization of a vertebrate and invertebrate comprising a virulent derivative of a pathogenic microbe said derivative being substantially incapable of producing functional adenylate cyclase and/or cyclic AMP receptor protein while being capable of expressing a recombinant gene derived from a pathogen of said vertebrate to produce an antigen capable of inducing an immune response in said vertebrate against said pathogen.

REFERENCES:
patent: 4550081 (1985-10-01), Stocker
Nnalue et al, Inf. & Imm. 1987 vol 55, pp. 955-962, Tests of the Virluence & Live Vaccine Efficacy of Auxotrophic & galE Derivatives of Salm. choleraesuis.
Crosa et al J of Bact, vol. 15, 115:301-315, 1973 Molecular Relationships Among the Salmonelleae.
Alper et al J. of Bact 133:149-157.
Komeda et al Molec. Gen Genet 142:289-298, 1975, The Role of cAMP in Flagellation of Salmonella typhimurium.
Wang et al PNAS 78:4684-4688 1981 Molecular Cloning & Amplification of the Adenylate Cyclase Gene.
Garges et al Cell 41:745-751 1985, Sites of Allosteric Shift in the Structures of the Cyclic AMP Receptor Protein.
Curtiss, III, et al., Infection and Immunity (1987) 55(12):3035-3043.
Nnalue et al., Microbial Pathogenesis (1989) 7:299-310.
Curtiss, III, et al., Immunological Investigations (1989) 18(1-4): 583-596.
Nakamura et al., Japan Journal of Veterinary Science (1988) 50:606-713.

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