Avirulent microbes and uses therefor

Details Avirulent microbes and uses therefor Avirulent microbes and uses therefor

1996-02-05

1999-01-05

Scheiner, Laurie

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

424 9348, 4241841, 4242001, 4242351, 4242571, 4242581, 4351723, 4352523, 43525233, 4353201, 435879, A61K 3902, A61K 39112, C12N 121

Patent

active

058558802

ABSTRACT:
This invention provides immunogenic compositions for the immunization of a vertebrate or invertebrate comprising an avirulent derivative of S. typhi. The derivatives having a mutation of the cya and/or crp and/or cdt genes. The invention also provides immunogenic compositions for the immunization of a vertebrate and invertebrate comprising an avirulent derivative of the above type which is capable of expressing a recombinant gene derived from a pathogen of said vertebrate or invertebrate individual to produce an antigen capable of inducing an immune response against said pathogen. Other embodiments of the invention include methods of preparing immunogenic compositions from these strains, and strains useful in the preparation of the immunogenic compositions, as well as methods of stimulating the immune system to respond to an immunogenic antigen of S. typhi by administration of the immunogenic composition.

REFERENCES:
patent: 4190495 (1980-02-01), Curtis
patent: 4837151 (1989-06-01), Stocker
Komeda et al., Molec. Gen. Genet. vol. 142, 289-298 (1975).
Ferrari et al., Biotechnology, vol. 3, Nov. 1985, pp. 1003-1007.
Jagusztyn-Krynicka et al., Journal of General Microbiology (1982) pp.1135-1145.

Affiliated with

Also associated with

Rating

Avirulent microbes and uses therefor does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Avirulent microbes and uses therefor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Avirulent microbes and uses therefor will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-859656